Infection of the endothelium by members of the order Rickettsiales

Gustavo Valbuena; David H. Walker

doi:10.1160/TH09-03-0186

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2009; 102(06): 1071-1079
DOI: 10.1160/TH09-03-0186

Theme Issue Article

Schattauer GmbH

Infection of the endothelium by members of the order Rickettsiales

Gustavo Valbuena

¹Department of Pathology and Center for Biodefense and Emerging Infectious Diseases, The University of Texas Medical Branch, Galveston, Texas, USA

,

David H. Walker

²Department of Pathology and Center for Biodefense and Emerging Infectious Diseases, The University of Texas Medical Branch, Galveston, Texas, USA

› Author Affiliations

Abstract

Summary

The vascular endothelium is the main target of a limited number of infectious agents; Rickettsia, Ehrlichia ruminantium, and Orientia tsutsugamushi are among them. These arthropod-transmitted obligately-intracellular bacteria cause serious systemic diseases that are not infrequently lethal. In this review, we discuss the bacterial biology, vector biology, and clinical aspects of these conditions with particular emphasis on the interactions of these bacteria with the vascular endothelium and how it responds to intracellular infection. The study of these bacteria in relevant in vivo models is likely to offer new insights into the physiology of the endothelium that have not been revealed by other models.

Keywords

Rickettsia - Orientia tsutsugamushi - Ehrlichia ruminantium - endothelium - blood circulation

Full Text

References

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