Protein S: An anticoagulant in its own right

Thromb Haemost 2012; 107(04): 601
DOI: 10.1160/TH12-01-0049

Invited Editorial Focus

Schattauer GmbH

Pablo García de Frutos

¹Department of Cell Death and Proliferation, Institute of Biomedical Research of Barcelona (IIBB-CSIC, IDIBAPS), Barcelona, Spain

References
1 Burstyn-Cohen T, Heeb MJ, Lemke G. Lack of pro-tei n S in mice causes embryonic lethal coagulopathy and vascular dysgenesis. J Clin Invest 2009; 119: 2942-2953.
2 Heeb MJ, Marzec U, Gruber A. et al. Antithrombotic activity of protein S infused without activated protein C in a baboon thrombosis model. Thromb Haemost 2012; 107: 690-698.
3 Heeb MJ, Prashun D, Griffin JH. et al. Plasma protein S contains zinc essential for efficient activated protein C-]independent anticoagulant activity and binding to factor Xa, but not for efficient binding to tissue factor pathway inhibitor. FASEB J 2009; 23: 2244-2253.
4 Hurtado B, Munoz X, Recarte-Pelz P. et al. Expression of the vitamin K-]dependent proteins GAS6 and protein S and the TAM receptor tyrosine kinases in human atherosclerotic carotid plaques. Thromb Haemost 2011; 105: 873-882.