Antithrombotic therapy in obesity

Lina Badimon; Rodrigo Hernández Vera; Teresa Padró; Gemma Vilahur

doi:10.1160/TH12-12-0928

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2013; 110(04): 681-688
DOI: 10.1160/TH12-12-0928

Theme Issue Article

Schattauer GmbH

Antithrombotic therapy in obesity

Lina Badimon

¹Centro de Investigación Cardiovascular, CSIC-ICCC, Hospital de la Santa Creu i Sant Pau and IIB-Santpau, Barcelona, Spain

²CIBEROBN Instituto de Salud Carlos III, Barcelona, Spain

³Cátedra de Investigación Cardiovascular, (UAB-HSCSP-Fundación Jesús Serra), Barcelona, Spain

,

Rodrigo Hernández Vera

¹Centro de Investigación Cardiovascular, CSIC-ICCC, Hospital de la Santa Creu i Sant Pau and IIB-Santpau, Barcelona, Spain

²CIBEROBN Instituto de Salud Carlos III, Barcelona, Spain

,

Teresa Padró

¹Centro de Investigación Cardiovascular, CSIC-ICCC, Hospital de la Santa Creu i Sant Pau and IIB-Santpau, Barcelona, Spain

²CIBEROBN Instituto de Salud Carlos III, Barcelona, Spain

,

Gemma Vilahur

¹Centro de Investigación Cardiovascular, CSIC-ICCC, Hospital de la Santa Creu i Sant Pau and IIB-Santpau, Barcelona, Spain

²CIBEROBN Instituto de Salud Carlos III, Barcelona, Spain

› Author Affiliations

Abstract

summary

Clinical management of obese subjects to reduce their risk of suffering cardiovascular events is complex. Obese patients typically require preventive strategies, life-style modifications, and multi-drug therapy to address obesity-induced co-morbidities. Data regarding the effects of excess weight on the pharmacokinetics of most drugs is scarce as these individuals are often excluded from clinical trials. However, the physiological alterations observed in obese patients and their lower response to some antiplatelet agents and anticoagulants have suggested that dosage regimes need to be adjusted for these subjects. In this review we will briefly discuss platelet alterations that can contributeto increased thrombotic risk, analyse existing data regarding the effects of obesity on drug pharmacokinetics focusing on antiplatelet agents and anticoagulants, and we will describe the beneficial effects of weight loss on thrombosis.

Keywords

Obesity - antiplatelets - anticoagulants

Full Text

References

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