More than a simple storage organ: Adipose tissue as a source of adipokines involved in cardiovascular disease

Gersina Rega-Kaun; Christoph Kaun; Johann Wojta

doi:10.1160/TH13-03-0212

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2013; 110(04): 641-650
DOI: 10.1160/TH13-03-0212

Theme Issue Article

Schattauer GmbH

More than a simple storage organ: Adipose tissue as a source of adipokines involved in cardiovascular disease

Gersina Rega-Kaun

¹Department of Internal Medicine II, Medical University Vienna, Austria

²5^th Department of Internal Medicine for Diabetes and Rheumatology, Wilhelminenhospital, Vienna, Austria

,

Christoph Kaun

¹Department of Internal Medicine II, Medical University Vienna, Austria

,

Johann Wojta

¹Department of Internal Medicine II, Medical University Vienna, Austria

³Core Facility, Medical University of Vienna, Austria

⁴Ludwig Boltzmann Cluster for Cardiovascular Research, Vienna, Austria

› Author Affiliations

Abstract

Summary

Overweight and obesity in many countries have developed into a serious health problem by themselves and by their impact on other pathologies such as insulin resistance, type 2 diabetes, hypertension, heart disease and cancer. The modulation of these diseases by adipose tissue-derived biomolecules, so-called adipokines, could be the key to differentiate between metabolically healthy and unhealthy obesity. This review will discuss the pathophysiological role of selected adipokines, primarily focusing on cardiovascular diseases. Furthermore, we will highlight possible therapeutic approaches, which target these biomolecules.

Keywords

Obesity - atherosclerosis - thrombosis

Full Text

References

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