Immune functions of platelets

Daniel Duerschmied; Christoph Bode; Ingo Ahrens

doi:10.1160/TH14-02-0146

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2014; 112(04): 678-691
DOI: 10.1160/TH14-02-0146

Theme Issue Article

Schattauer GmbH

Immune functions of platelets

Daniel Duerschmied

¹Department of Cardiology and Angiology I, Heart Center, University of Freiburg, Freiburg, Germany

,

Christoph Bode

¹Department of Cardiology and Angiology I, Heart Center, University of Freiburg, Freiburg, Germany

,

Ingo Ahrens

¹Department of Cardiology and Angiology I, Heart Center, University of Freiburg, Freiburg, Germany

› Author Affiliations

Abstract

Summary

This review collects evidence about immune and inflammatory functions of platelets from a clinician’s point of view. A focus on clinically relevant immune functions aims at stimulating further research, because the complexity of platelet immunity is incompletely understood and not yet translated into patient care. Platelets promote chronic inflammatory reactions (e.g. in atherosclerosis), modulate acute inflammatory disorders such as sepsis and other infections (participating in the host defense against pathogens), and contribute to exacerbations of autoimmune conditions (like asthma or arthritis). It would hence be obsolete to restrict a description of platelet functions to thrombosis and haemostasis – platelets clearly are the most abundant cells with immune functions in the circulation.

Keywords

Platelet immunology - sepsis - leukocyte function/activation

Full Text

References

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