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Thromb Haemost 2016; 115(01): 169-175
DOI: 10.1160/TH15-02-0148
Stroke, Systemic or Venous Thromboembolism
Schattauer GmbH Schattauer

Serum levels of 25(OH)D are not associated with venous thromboembolism in the elderly population

A case-control study
Marion Andro
1   Université de Bretagne Occidentale, EA 3878, Brest, France
2   CHRU Brest, Département de gériatrie, Brest, France
,
Aurélien Delluc
1   Université de Bretagne Occidentale, EA 3878, Brest, France
,
Marie-Pierre Moineau
3   CHRU Brest, Département de biochimie, Brest, France
,
Cécile Tromeur
1   Université de Bretagne Occidentale, EA 3878, Brest, France
,
Maelenn Gouillou
4   INSERM, Centre d’investigation clinique CIC 1412, Brest, France
,
Karine Lacut
1   Université de Bretagne Occidentale, EA 3878, Brest, France
4   INSERM, Centre d’investigation clinique CIC 1412, Brest, France
,
Jean-Luc Carré
3   CHRU Brest, Département de biochimie, Brest, France
,
Armelle Gentric
2   CHRU Brest, Département de gériatrie, Brest, France
5   Université de Bretagne Occidentale, EA 4686, Brest, France
,
Grégoire Le Gal
1   Université de Bretagne Occidentale, EA 3878, Brest, France
6   Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Canada
› Author Affiliations
Further Information

Publication History

Received: 05 March 2015

Accepted after major revision: 15 July 2015

Publication Date:
22 November 2017 (online)

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Summary

The prevalence of both vitamin D deficiency and venous thromboembolism (VTE) is important in the elderly. Previous studies have provided evidence for a possible association between vitamin D status and the risk of VTE. Thus, we aimed to investigate the association between vitamin D levels and VTE in the population aged 75 and over included in the EDITH case-control study. The association between vitamin D status and VTE was analysed. We also analysed the monthly and seasonal variations of VTE and vitamin D. Between May 2000 and December 2009, 340 elderly patients (mean age 81.5 years, 32 % men) with unprovoked VTE and their controls were included. The univariate and multivariate analysis found no significant association between serum levels of vitamin D and the risk of unprovoked VTE. In the unadjusted analysis, a higher BMI was statistically associated with an increased risk of VTE (OR 1.09; 95 % CI 1.05–1.13) whereas a better walking capacity and living at home were associated with a decreased rate of VTE: OR 0.57; 95 % CI 0.36–0.90 and 0.40; 95 % CI 0.25–0.66, respectively. Although not significant, more VTE events occurred during winter (p=0.09). No seasonal variations of vitamin D levels were found (p=0.11). In conclusion, in contrast with previous reports our findings suggest that vitamin D is not associated with VTE in the elderly population.

Keywords

Vitamin D - venous thromboembolism - aged - risk factors - case-control study
 

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