Regulation of sterile inflammation in the natural resolution of venous thrombosis

Thromb Haemost 2015; 114(05): 875
DOI: 10.1160/TH15-09-0750

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Schattauer GmbH

Insight TLR9, expressed on macrophages, appears to be important for normal thrombus resolution….

Authors

Prakash Saha

¹Academic Department of Vascular Surgery, Cardiovascular Division, British Heart Foundation Centre of Research Excellence, Kings College London, St Thomas′ Hospital, London, UK
Alberto Smith

¹Academic Department of Vascular Surgery, Cardiovascular Division, British Heart Foundation Centre of Research Excellence, Kings College London, St Thomas′ Hospital, London, UK

References
1 Saha P, Humphries J, Modarai B. et al. Leukocytes and the natural history of deep vein thrombosis: current concepts and future directions. Arterioscl Thromb Vasc Biol 2011; 31: 506-512.
2 Chen GY, Nunez G. Sterile inflammation: sensing and reacting to damage. Nat Rev Immunol 2010; 10: 826-837.
3 Dwyer NA, El-Sayed OM, Luke CE. et al. Thromb Haemost 2015; 114: 1028-1037.
4 Varju I, Longstaff C, Szabo L. et al. DNA, histones and neutrophil extracellular traps exert anti-fibri-nolytic effects in a plasma environment. Thromb Haemost 2015; 113: 1289-1298.
5 Saha P, Andia ME, Modarai B. et al. Magnetic resonance T1-relaxation time of venous thrombus is determined by iron processing and predicts susceptibility to lysis. Circulation 2013; 128: 729-736.