L-homoarginine administration reduces neointimal hyperplasia in balloon-injured rat carotids

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• References

• 1 Hoefer IE, Steffens S, Ala-Korpela M. et al. Novel methodologies for biomarker discovery in atherosclerosis. Eur Heart J 2015; 36: 2635-2642.
• 2 Kakoki M, Kim HS, Edgell CJ. et al. Amino acids as modulators of endothelium-derived nitric oxide. Am J Physiol Renal Physiol 2006; 291: F297-F304.
• 3 Valtonen P, Laitinen T, Lyyra-Laitinen T. et al. Serum L-homoarginine concentration is elevated during normal pregnancy and is related to flow-mediated vasodilatation. Circ J 2008; 72: 1879-1884.
• 4 März W, Meinitzer A, Drechsler C. et al. Homoarginine, cardiovascular risk, and mortality. Circulation 2010; 122: 967-975.
• 5 Moali C, Boucher JL, Sari MA. et al. Substrate specificity of NO synthases: detailed comparison of L-arginine, homo-L-arginine, their N omega-hydroxy derivatives, and N omega-hydroxynor-L-arginine. Biochemistry 1998; 37: 10453-10460.
• 6 Hrabák A, Bajor T, Temesi A. Comparison of substrate and inhibitor specificity of arginase and nitric oxide (NO) synthase for arginine analogues and related compounds in murine and rat macrophages. Biochem Biophys Res Commun 1994; 198: 206-212.
• 7 Kakoki M, Kim HS, Arendshorst WJ. et al. L- Arginine uptake affects nitric oxide production and blood flow in the renal medulla. Am J Physiol Regul Integr Comp Physiol 2004; 287: R1478-R1485.
• 8 Pilz S, Meinitzer A, Tomaschitz A. et al. Low homoarginine concentration is a novel risk factor for heart disease. Heart 2011; 97: 1222-1227.
• 9 Drechsler C, Meinitzer A, Pilz S. et al. Homoarginine, heart failure, and sudden cardiac death in haemodialysis patients. Eur J Heart Fail 2011; 13: 852-859.
• 10 Pilz S, Meinitzer A, Gaksch M. et al. Homoarginine in the renal and cardiovascular systems. Amino Acids 2015; 47: 1703-1713.
• 11 Atzler D, Schwedhelm E, Choe CU.. L-homoarginine and cardiovascular disease. Curr Opin Clin Nutr Metab Care 2015; 18: 83-88.
• 12 Choe CU, Atzler D, Wild PS. et al. Homoarginine levels are regulated by L-arginine:glycine amidinotransferase and affect stroke outcome: results from human and murine studies. Circulation 2013; 128: 1451-1461.
• 13 Kleber ME, Seppälä I, Pilz S. et al. Genome-wide association study identifies 3 genomic loci significantly associated with serum levels of homoarginine: the AtheroRemo Consortium. Circ Cardiovasc Genet 2013; 6: 505-513.
• 14 Davids M, Ndika JD, Salomons GS. et al. Promiscuous activity of arginine:glycine amidinotransferase is responsible for the synthesis of the novel cardiovascular risk factor homoarginine. FEBS Lett 2012; 586: 3653-3657.
• 15 Ohwada T, Ishibashi T, Yaoita H. et al. Different contribution of apoptosis to the antiproliferative effects of L-arginine, enalapril and losartan on neointimal growth inhibition after balloon arterial injury. Circ J 2002; 66: 965-971.
• 16 Teerlink T, Nijveldt RJ, de Jong S. et al. Determination of arginine, asymmetric dimethylarginine, and symmetric dimethylarginine in human plasma and other biological samples by high-performance liquid chromatography. Anal Biochem 2002; 303: 131-137.
• 17 Wang BS, Huang GJ, Lu YH. et al. Anti-inflammatory effects of an aqueous extract of Welsh onion green leaves in mice. Food Chem 2013; 138: 751-756.
• 18 Forbes SP, Alferiev IS, Chorny M. et al. Modulation of NO and ROS production by AdiNOS transduced vascular cells through supplementation with L- Arg and BH4: implications for gene therapy of restenosis. Atherosclerosis 2013; 2301: 23-32.
• 19 Durante W.. Role of arginase in vessel wall remodeling. Front Immunol 2013; 4: 111.