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Vet Comp Orthop Traumatol 2012; 25(02): 160-166
DOI: 10.3415/VCOT-11-04-0049
Case Report
Schattauer GmbH

Primary synovial osteochondromatosis of the stifle in an English Mastiff

T. J. Smith
1   Department of Clinical Science, College of Veterinary Medicine, Oregon State University, Corvallis, Oregon, USA
,
W. I. Baltzer
1   Department of Clinical Science, College of Veterinary Medicine, Oregon State University, Corvallis, Oregon, USA
,
C. Löhr
2   Department of Biomedical Sciences, College of Veterinary Medicine, Oregon State University, Corvallis, USA
,
S. M. Stieger-Vanegas
1   Department of Clinical Science, College of Veterinary Medicine, Oregon State University, Corvallis, Oregon, USA
› Author Affiliations
Further Information

Publication History

Received 04 April 2011

Accepted 21 January 2011

Publication Date:
23 December 2017 (online)

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Summary

A two-year-old, 97 kg, male neutered English Mastiff was evaluated for left pelvic limb lameness of five months duration localized to the stifle joint. Following radiographic, computed tomographic and arthroscopic examination, the lameness was subsequently diagnosed as being caused by primary synovial osteochondromatosis. In total, 194 osteochondral bodies were removed using arthroscopy in combination with a mini-arthrotomy. Histology and immunohistochemistry of the loose osteochondral fragments confirmed the diagnosis with a moderately high degree of differentiation and low cellularity. Nuclear staining for Ki-67 revealed decreasing differentiation and increasing cellularity in the fragments. At the 13 months telephone follow-up the owner reported that the dog was free from lameness and had a vastly improved function compared with preoperative levels, although mild lameness did occasionally occur. This is the first report of computed tomography, arthroscopy and immunohistochemistry confirming a case of primary synovial osteochondromatosis in a dog.

Keywords

Osteochondromatosis - Ki-67 - dog - stifle - arthroscopy
 

  • References

  • 1 Flo GL, Stickle RL, Dunstan RW. Synovial chondrometaplasia in five dogs. J Am Vet Med Assoc 1987; 191: 1417-1422.
    PubMedGoogle Scholar
  • 2 Gregory SP, Pearson GR. Synovial osteochondromatosis in a Labrador Retriever bitch. J Small Animal Pract 1990; 31: 580-583.
    CrossrefPubMedGoogle Scholar
  • 3 Edinger DT, Manley PA. Arthrodesis of the shoulder for synovial osteochondromatosis. J Small Animal Pract 1998; 39: 397-400.
    CrossrefPubMedGoogle Scholar
  • 4 Piermattei DL, Flo GL, DeCamp CE. Miscellaneous conditions of the musculoskeletal system. In: Brinker, Piermattei and Flo's Handbook of Small Animal Orthopedics and Fracture Repair. Missouri: Saunders; 2006. pg. 775-790.
    Google Scholar
  • 5 Schajowicz F. Tumors and tumor-like lesions of bone and joints. New York: Springer-Verlag; 1981
    Google Scholar
  • 6 Mackenzie G, Raby N, Ritchie D. A pictorial review of primary synovial osteochondrmatosis. Eur Radiol 2008; 18: 2662-2669.
    CrossrefPubMedGoogle Scholar
  • 7 Von linddern JJ, Theuerkauf I, Niederhagen B. et al. Synovial chondromatosis of the temporomandibular joint: clinical, diagnostic and histomorphologic findings. Oral Surg Oral Med Oral Pathol Radiol Endod 2002; 94: 31-38.
    CrossrefPubMedGoogle Scholar
  • 8 Thompson K. Diseases of joints. In: Maxie MG. editor. Jubb, Kennedy, and Palmer's Pathology of Domestic Animals. New York: Elsevier Ltd; 2007. pg. 130-136.
    Google Scholar
  • 9 Nakanishi S, Sakamoto K, Yoshitake H. et al. Bone morphogenetic proteins are involved in the pathobiology of synovial chondromatosis. Biochem Biophy Res Commun 2009; 379: 914-919.
    CrossrefPubMedGoogle Scholar
  • 10 Pool RR, Thompson KG. Tumors of joints. In: Meuten DJ. editor. Tumors in Domestic Animals. Ames, Iowa: Iowa State Press; 2002. pg. 199-243.
    Google Scholar
  • 11 Diaz-Bertrana C, Durall I, Rial JM. et al. Extra- and intra-articular synovial chondromatosis and malignant transformation to chondrosarcoma. Vet Comp Orthop Traumatol 2010; 23: 277-283.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 12 Tutan S, Ozgonenel L, Cetin E. et al. Two rare involvement sites: synovial chondromatosis. Rheumtol Int 2011; 31: 687-689.
    PubMedGoogle Scholar
  • 13 Davis RI, Foster H, Biggart DJ. C-erb B-2 staining in primary synovial chondromatosis: A comparison with other cartilaginous tumors. J Path 1996; 179: 392-395.
    CrossrefPubMedGoogle Scholar
  • 14 Davis RI, Foster H, Arthur K. et al. Cell proliferation studies in primary synovial chondromatosis. J Path 1998; 184: 18-23.
    CrossrefPubMedGoogle Scholar
  • 15 Geels JJ, Roush JK, Hoskinson JJ. et al. Evaluation of an intracapsular technique for the treatment of cranial cruciate ligament rupture. Vet Comp Orthop Traumatol, 2000; 13: 197-203.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 16 Schulz KS. What's new in elbow arthroscopy. Proceedings of the 13th Annual American College of Veterinary Surgeons Symposium. 2003. October 9 Washington DC, USA: pg. 329-331.
    Google Scholar
  • 17 Pool RR. Osteochondromatosis. In: Borjab MJ. editor. Disease Mechanisms in Small Animal Surgery. Malvern, PA: Lea and Febiger, Malvern; 1993. pg. 821-833.
    Google Scholar
  • 18 Thompson KG, Pool RR. Tumors of bones. In: Meuten DJ. Tumors of domestic animals. Ames, IA: Iowa State Press; 2002. pg. 245-317.
    Google Scholar
  • 19 Kay PR, Freemont AJ, Davies DRA. The aetiology of multiple loose bodies: Snow Storm Knee. J Bone Joint Surg 1989; 71: 501-504.
    PubMedGoogle Scholar
  • 20 Imhoff A, Schreiber A. Synovial chondromatosis. Orthopade 1988; 17: 233-244.
    PubMedGoogle Scholar
  • 21 Saotome K, Tamai K, Koguchi Y. et al. Growth potential of loose bodies: an immunohistochemical examination of primary and secondary synovial osteochondromatosis. J Orthop Res 1999; 17: 73-79.
    CrossrefPubMedGoogle Scholar
  • 22 Maurice H, Crone M, Watt I. Synovial chondromatosis. J Bone Joint Surg Br 1988; 70: 807-811.
    Google Scholar
  • 23 Shpitzer T, Ganel A, Engelberg S. Surgery for synovial chondromatosis: 26 cases followed up for 6 years. Acta Orthop Scand 1990; 61: 567-569.
    CrossrefPubMedGoogle Scholar
  • 24 Batheja NO, Wang BY, Springfiled D. et al. Fine needle aspiration diagnosis of synovial chondromatosis of the tibiofibular joint. Ann Diag Pathl 2000; 4: 77-80.
    PubMedGoogle Scholar
  • 25 Scully SP, Layfield LJ, Harrelson JM. Prognostic markers in chondrosarcoma: evaluation of cell proliferation and of regulators of the cell cycle. Sarcoma 1997; 1: 79-87.
    CrossrefPubMedGoogle Scholar