Keywords
Cantwell–Ransley repair - epispadias in adult - repair
INTRODUCTION
Isolated epispadias with continence is very rare entity comprising <10% of all epispadias
cases[1] and that to in adult is extremely rare since such anomalies are usually treated
surgically in early childhood.[2] Epispadias repair remains challenge to reconstructive surgeons. Challenges in adult
patients include long-term changes affecting the urethral mucosa and surrounding tissue
as well as concern about the sexual potential.[2]
[3] Many surgical techniques have been described for the repair of the male epispadias
of which modified Cantwell–Ransley has become the procedure of choice.[4]
We are presenting results of our experience in performing modified Cantwell–Ransley
repair in five continent adult males having various types of isolated epispadias and
for its rarity.
MATERIALS AND METHODS
Isolated epispadias repair was performed in five male adult patients (age ranged from
15 to 25 years) from 2011 to 2016 by a single surgeon. Among them two were in 15–20
years and three were in 20–25 years age group.
All five cases had isolated continent epispadias with one patient had a history of
repair in childhood, but exact surgical details were not known. Out of five patients,
two were mid-penile, two cases of proximal penile and one were penopubic [Figure 1]. All five cases were continent. In all cases, exposed ventral urethral plate was
of adequate width and having mild dorsal chordee and scrotal examination revealed
normal tests in all cases. None of the patients had vesicoureteric reflux. All cases
had fused symphysis pubis. Kidneys and other intra-abdominal organs were normal on
ultrasonography or non-contrast computerised tomogram [Figure 2]. Basic biochemical tests were normal in all the cases. All cases underwent examination
under anaesthesia on cystourethroscopy posterior urethra and verumontanum seen and
bladder capacity was adequate. Pre-operative testosterone was not used for increasing
the penile length. All patients underwent repair under general anaesthesia by modified
Cantwell–Ransley technique as described in detail by Gearhart. Traction suture placed
into each hemiglans in transverse orientation. Circumcising incision with urethral
strip extension on lateral edges of urethral plate and around the hypospadiac meatus.
Degloving of penis correction of chordee was checked by intra-operative Gittes test.
The urethral plate was dissected away from the corpora except for the distal most
1–1.5 cm so as to get the urethra deeper under the corpora at the glans level [Figure 3]. Urethra is tubularised using Vicrly 5-0 continuous subcuticular fashion over 12
Fr foleys catheter. Medial rotation of corpora over urethra is done using delayed
absorbable sutures in an interrupted fashion without incision and anastomosis [Figure 4].
Figure 1: Clinical photograph of penopubic epispadias
Figure 2: Non-contrast computerised tomogram showing fused symphysis pubis
Figure 3: Both corporal bodies dissected away from corpora
Figure 4: Medial rotation and dorsal approximation of corporal bodies
Glanuloplasty was done. Skin closed with reversed Byar's flap. The erection was suppressed
in post-operative period for 10 days by giving tablet Calmpose 5 mg at bedtime. In
all cases, suprapubic cystostomy was done as a proximal diversion. Anticholinergic
was started immediately after the surgery till catheter removal to decrease bladder
spasm and to enhance patients comfort. The dressing was opened on the 7th post-operative day. The per-urethral catheter was removed on the 14th post-operative day, and suprapubic catheter was clamped. All patients voided with
a good stream and maintained continence post-operatively [Figure 5]. After 48 h, the suprapubic catheter was removed. All patients were followed up
at 1, 3, 6 months and yearly thereafter for outcome. On follow-up, patients were assessed
by physical evaluation and gentle placing of the catheter at 3 months and 6 months
to check the patency. We assessed flaccid unstretched penile length from penopubic
junction to the tip of the penis in standing position pre-operatively and at 3 months
post-operatively.
Figure 5: Epispadias repair completed
RESULTS
Follow-up ranges from 6 months to 5 years. All patients had satisfactory cosmetic
appearance with conical orthotopic meatus with penile direction downwards on standing
position. The post-operative penile length was unchanged except insignificant gain
in two cases (approximately 1 cm), and there was complete correction of dorsal chordee.
None of the patients developed meatal stenosis, diverticulum, stricture, fistula or
incontinence post-operatively. One patient had superficial skin infection dorsally
which was healed by secondary intention without the need for resuturing or grafting.
All patients were able to achieve a straight erection. Urethral catheterisation with
the smooth urethral tube at 3 months and 6 months was easy in all five patients.
DISCUSSION
Epispadias is a rare congenital anomaly usually present at one end of the spectrum
of bladder exstrophy-epispadias complex.[1]
[2] It is very unusual for patients with isolated epispadias to present for the first
time in adult.[5] Braga et al. reported mean patient age at epispadias surgery using Cantwell–Ransley repair to
be 16.8 months.[6] Delayed presentation of all of our patients may be due to poverty and ignorance
as all of them from remote villages however one case had prior history of repair.
In a series of Hafez and Helmy, all cases presented in post-pubertal life with the
prior history of failed repair.[7]
Several surgical procedures have been described till date but treatment for this anomaly
is far from trival and repair can be challenging.[4] The goal of surgery is to achieve functionally and cosmetically acceptable penis.[8] The first description of epispadias repair is by Cantwell in 1895 till then techniques
evolved through various modification. Finally, there are two popular techniques described
in literature, that is, modified Cantwell–Ransley which involves partial penile disassembly
of penis and placement of urethra in more normal position and the second most recent
evolution is complete penile disassembly.[4]
Despite the versatility of Mitchell technique, it may lead to ischaemic changes to
distal glans, loss of glans or corpora and the shortening of urethral plate with resultant
hypospadias have been reported.[9] The Cantwell–Ransley repair is an excellent, most popular and widely used approach
to treat epispadias compared to other standard methods. However, this technique has
drawback, the most distal portion of corpora cavernosa and urethral plate also not
dissected and mobilised leads to inadequate ventralisation of meatus and formation
of fistula at coronal sulcus level.[3]
[8]
To avoid drawbacks of both techniques, various modifications have been described.
Perovic et al. described to leave the distal end of urethral plate attached to both hemiglans to
circumvent the problem of shortening to avoid the drawback of Mitchell technique.[3]
To avoid drawbacks of Cantwell–Ransley repair, Gearhart described modification as
the urethral mucosal plate was dissected away from the corpora except for the distal
most 1–1.5 cm so as to get urethra deeper under the corpora at glans level.[8]
[10] Mitchell technique is more ideal for epispadias cases associated with bladder exstrophy
and incontinent penopubic epispadias.[11]
Considering isolated continent epispadias, surgeons preference and expertise, we used
modified Cantwell–Ransley technique described by Gearhart in all five cases including
the one who had a history of repair in childhood. By this method, all five cases achieved
orthotopic conical meatus, and none had ischaemic changes in glans.
Modified Cantwell–Ransley technique can also be used as salvage procedure as successfully
used by Surer et al. in his six cases who had prior failed urethroplasty.[10]
[12]
We also feel that in treating the case of isolated epispadias complete penile disassembly
with dissection of corpora proximal to penopubic region will not add any real advantage
as also reported by Mokhless et al.[11]
In cases of isolated epispadias, only the urethra gets affected; however, the involvement
of bladder neck occurs in few cases. Urinary incontinence may thus result if the defect
is proximal enough to affect the sphincter mechanism.[13] As all our cases had isolated epispadias continence which was maintained after surgery
also. Bansal et al. treated two cases of epispadias by modified Cantwell–Ransley technique and continence
was maintained in both of his cases post-operatively.[1] Up to 70% males with penopubic epispadias had widely separated bones of pelvis affecting
bladder neck and external sphincter leading to incontinence or stress urinary incontinence.[14] However, in our series, only one patient had penopubic epispadias who had fused
symphysis pubis and not having incontinence.
Technique to improve dorsal chordee before urethroplasty is ventral shortening of
corpora or medial rotation of ventral corpora described by Koff and Eakins.[15] Corporal rotation can be done either by incision and anastomosis where the dissection
of neurovascular bundle is necessary or without incision and anastomosis with an approximation
of corpora by delayed absorbable sutures.[10] Whether simple rotation of corpora is adequate or corporal incision and anastomosis
are really required a judgement call at the time of surgery.[12] For cases with severe chordee and older patients, incision and anastomosis technique
of rotation are required.[10]
In our series, all cases had mild dorsal chordee which was corrected by medial rotation
without incision and anastomosis and achieved a direction of penis either downwards
or horizontal in standing position post-operatively. Proximal diversion is used for
several weeks, which will lower fistula formation.[12] We also place suprapubic cystostomy as proximal diversion as an additional safety
and to avoid fistula formation in all cases.
None of the current epispadias repair offers any significant gain in penile length
by removing entire urethral plate from glans or even using free graft.[10] Gain in penile length is achieved by straightening the penis and not by adding the
length to corporal bodies.[16] The claim that penile length may be affected using modified rather than the complete
penile disassembly technique is incorrect.[9] El-Sherbiny and Hafez found no significant difference in mean penile length between
the two techniques.[17]
In our series, also, unstretched length of the penis before and after surgery is either
unchanged or within significant gain in length post-operatively.
Complications following epispadias repair include the development of urethrocutaneous
fistula, persistent chordee, difficulty in urethral catheterisation and erectile dysfunction.[8] Reported fistula rate for Cantwell–Ransley repair ranges from 5% to 20%.[10] Nerli et al. treated 43 cases of epispadias by modified Cantwell–Ransley technique and had 16.27%
fistula rate.[8] Fistula rate of 4% and urethral stricture rate of 5.3% reported by Gearhart and
Mathews.[14] In our series, no patient developed fistula or stricture (although our series comprises
of five cases only) similar to findings of Pippi Salle et al.[18] In the report of two cases of epispadias repair by modified Cantwell–Ransley by
Lodh et al., there is no fistula or need for any dilatation post-operatively.[4]
Only one patient had superficial infection of dorsal penile skin which healed by secondary
intention and did not require a secondary procedure in our series. In series of Nerli
et al. of 43 cases treated by similar technique found dorsal skin infection or incision
separation in three children and none required a secondary procedure in his series.[8]
Pippi Salle et al. used ventral rotational skin flap in nine patients for dorsal skin closure found
improved cosmesis and decreased recurrence of chordee secondary to midline dorsal
scarring.[18]
No impotence, due to Cantwell–Ransley procedure, has been reported in literature as
dissection is not carried out too far under the pubic bone. There is no risk of injury
to cavernosal artery or erectile nerves.[19] Atim and Mustapha reported a case of penopubic epispadias treated by modified Cantwell–Ransley
technique, and in his single case, erection was maintained post-operatively.[2] Reddy et al. in their assessment of sexual health outcome in adults with complete male epispadias
post-reconstruction noted 80% of their patients had overall satisfactory sexual intercourse.[20] In our series of five cases, all were able to achieve and maintain erection up to
5 years follow-up. Out of five cases, only one was married who had satisfactory sexual
life post-operative.
Penile cosmesis following repair is subjective measurement and differs for surgeon
and patients.[1] Lottmann et al. in series of forty patients reported 90% successful anatomic and functional results
following repair at a mean follow-up of 3 years.[19] In our series at the end of maximum 5 years follow-up and a minimum follow-up of
6 months, all five cases had satisfactory cosmesis with successful anatomic and functional
results [Figures 6]
[7]
[8].
All our patients were adults having isolated epispadias with adequate penile length.
No one has pubic diastasis, so the approximation of corpora is easier. All cases are
continent, so there is no peri-catheter leak which increases the chances of infection
and fistula formation. Hence, meticulous dissection, perfect hemostasis, proximal
urinary diversion and proper approximation of corpora to cover urethral suture site
is key for success.
Figure 6: Clinical photograph showing excellent cosmetic results taken at 4 years follow-up
Figure 7: Clinical photograph showing excellent functional results taken at 4 years follow-up
Figure 8: Clinical photograph showing good stream post-operatively
CONCLUSION
Isolated continent epispadias in adults is extremely rare but not uncommon. Modified
Cantwell–Ransley repair is well suited for primary as well as failed cases in adults
with isolated epispadias and provide excellent anatomical, functional results with
good cosmesis and improves the quality of life of patients.
Financial support and sponsorship
Nil.
