Appl Clin Inform 2015; 06(03): 548-564
DOI: 10.4338/ACI-2015-02-RA-0021
Research Article
Schattauer GmbH

Transition Networks in a Cohort of Patients with Congestive Heart Failure

A novel application of informatics methods to inform care coordination
J. A. Merrill
1   Columbia University Medical Center, New York, NY, United States
,
B. M. Sheehan
2   Division of Health and Life Sciences, Intel Corporation, Santa Clara, CA, United States
,
K. M. Carley
3   Institute of Software Research, Carnegie Mellon University, Pittsburgh, PN, United States
,
P. D. Stetson
4   Memorial Sloan Kettering Cancer Center, New York, NY, United States
› Author Affiliations
Further Information

Correspondence to:

Jacqueline A Merrill, PhD, MPH, RN
Associate Professor of Nursing in Biomedical Informatics
Columbia University Medical Center
617 West 168th Street, Georgian 226
New York, New York 10034
Phone: 212 305 3194   

Publication History

received: 27 February 2015

accepted in revised form: 10 July 2015

Publication Date:
19 December 2017 (online)

 

Summary

Background: Unnecessary hospital readmissions are one source of escalating costs that may be reduced through improved care coordination, but how best to design and evaluate coordination programs is poorly understood. Measuring patient flow between service visits could support decisions for coordinating care, particularly for conditions such as congestive heart failure (CHF) which have high morbidity, costs, and hospital readmission rates.

Objective: To determine the feasibility of using network analysis to explore patterns of service delivery for patients with CHF in the context of readmissions.

Methods: A retrospective cohort study used de-identified records for patients 18 years with an ICD-9 diagnosis code 428.0–428.9, and service visits between July 2011 and June 2012. Patients were stratified by admission outcome. Traditional and novel network analysis techniques were applied to characterize care patterns.

Results: Patients transitioned between services in different order and frequency depending on admission status. Patient-to-service CoUsage networks were diffuse suggesting unstructured flow of patients with no obvious coordination hubs. In service-to-service Transition networks a specialty heart failure service was on the care path to the most other services for never admitted patients, evidence of how specialist care may prevent hospital admissions for some patients. For patients admitted once, transitions expanded for a clinic-based internal medicine service which clinical experts identified as a Patient Centered Medical Home implemented in the first month for which we obtained data.

Conclusions: We detected valid patterns consistent with a targeted care initiative, which experts could understand and explain, suggesting the method has utility for understanding coordination. The analysis revealed strong but complex patterns that could not be demonstrated using traditional linear methods alone. Network analysis supports measurement of real world health care service delivery, shows how transitions vary between services based on outcome, and with further development has potential to inform coordination strategies.

Citation: Merrill JA, Sheehan BM, Carley KM, Stetson PD. Transition networks in a cohort of patients with congestive heart failure: a novel application of informatics methods to inform care coordination. Appl Clin Inform 2015; 6: 548–564

http://dx.doi.org/10.4338/ACI-2015-02-RA-0021


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Conflict of Interest

At the time of the study PDS was CIO/CMIO at Columbia Doctors Faculty Practice and BS was Director of Quality Informatics. The other authors declare no conflicts of interest.

  • References

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  • 2 Institute of Medicine.. The Healthcare Imperative: Lowering Costs and Improving Outcomes: Workshop Series Summary. In: Yong PL, Saunders RS, Olsen LA. editors. Vol 3 Inefficiently Delivered Services, Roundtable on Evidence-Based Medicine. Washington, DC: National Academies Press; 2010
  • 3 Institute of Medicine.. Best Care at Lower Cost: The Path to Continuously Learning Health Care in America. Washington, DC: National Academy of Sciences; 2012
  • 4 Guterman S, Davis K, Schoenbaum S, Shih A. Using Medicare Payment Policy To Transform The Health System: A Framework For Improving Performance. Health Aff 2009; 28 (02) w238-w250.
  • 5 Landon BE, Keating NL, Barnett ML, Onnela JP, Paul S, O’Malley AJ, Keegan T, Christakis NA. Variation in patient-sharing networks of physicians across the United States. JAMA 2012; 308 (03) 265-273.
  • 6 National Quality Forum.. Effective Communication and Care Coordination [cited 2015 February 9]. Available from: http://www.qualityforum.org/Topics/Effective_Communication_and_Care_Coordination.aspx
  • 7 Agency for Healthcare Research and Quality (AHRQ).. National Strategy for Quality Improvement in Health Care. Rockville, MD: Department of Health and Human Services; 2011
  • 8 Asaro PV, Sheldahl AL, Char DM. Embedded guideline information without patient specificity in a commercial emergency department computerized order-entry system. Acad Emerg Med 2006; 13 (04) 452-458.
  • 9 Handler JA, Feied CF, Coonan K, Vozenilek J, Gillam M, Peacock PR, Sinert R, Smith MS. Computerized physician order entry and online decision support. Acad Emerg Med 2004; 11 (11) 1135-1141.
  • 10 Press MJ, Michelow MD, MacPhail LH. Care coordination in accountable care organizations: moving beyond structure and incentives. Am J Manag Care 2012; 18 (12) 778-780.
  • 11 Agency for Healthcare Research and Quality (AHRQ).. Closing the quality gap: A critical analysis of quality improvement strategies. Rockville, MD.: AHRQ; 2007
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  • 13 Takeda A, Taylor SJ, Taylor RS, Khan F, Krum H, Underwood M. Clinical service organisation for heart failure. Cochrane Database Syst Rev 2012; 9: CD002752.
  • 14 Dharmarajan K, Hsieh AF, Lin Z, Bueno H, Ross JS, Horwitz LI, Barreto-Filho JA, Kim N, Bernheim SM, Suter LG, Drye EE, Krumholz HM. Diagnoses and timing of 30-day readmissions after hospitalization for heart failure, acute myocardial infarction, or pneumonia. JAMA 2013; 309 (04) 355-363.
  • 15 Krumholz HM, Merrill AR, Schone EM, Schreiner GC, Chen J, Bradley EH, Wang Y, Wang Y, Lin Z, Straube BM, Rapp MT, Normand SL, Drye EE. Patterns of hospital performance in acute myocardial infarction and heart failure 30-day mortality and readmission. Circulation Cardiovascular quality and outcomes 2009; 2 (05) 407-413.
  • 16 Jencks SF, Williams MV, Coleman EA. Rehospitalizations among patients in the Medicare fee-for-service program. The New England journal of medicine 2009; 360 (14) 1418-1428.
  • 17 Ross JS, Chen J, Lin Z, Bueno H, Curtis JP, Keenan PS, Normand SL, Schreiner G, Spertus JA, Vidan MT, Wang Y, Wang Y, Krumholz HM. Recent national trends in readmission rates after heart failure hospitalization. Circ Heart Fail 2010; 3 (01) 97-103.
  • 18 Au AG, McAlister FA, Bakal JA, Ezekowitz J, Kaul P, van Walraven C. Predicting the risk of unplanned readmission or death within 30 days of discharge after a heart failure hospitalization. American heart journal 2012; 164 (03) 365-372.
  • 19 Coffey RM, Misra A, Barrett M, Andrews RM, Mutter R, Moy E. Congestive heart failure: who is likely to be readmitted?. Medical care research and review MCRR 2012; 69 (05) 602-616.
  • 20 Wallmann R, Llorca J, Gomez-Acebo I, Ortega AC, Roldan FR, Dierssen-Sotos T. Prediction of 30-day cardiac-related-emergency-readmissions using simple administrative hospital data. International journal of cardiology 2013; 164 (02) 193-200.
  • 21 Ross JS, Mulvey GK, Stauffer B, Patlolla V, Bernheim SM, Keenan PS, Krumholz HM. Statistical models and patient predictors of readmission for heart failure: a systematic review. Arch Intern Med 2008; 168 (13) 1371-1386.
  • 22 Gwadry-Sridhar FH, Flintoft V, Lee DS, Lee H, Guyatt GH. A systematic review and meta-analysis of studies comparing readmission rates and mortality rates in patients with heart failure. Arch Intern Med 2004; 164 (21) 2315-2320.
  • 23 Barnett ML, Christakis NA, O’Malley J, Onnela JP, Keating NL, Landon BE. Physician patient-sharing networks and the cost and intensity of care in US hospitals. Med Care 2012; 50 (02) 152-160.
  • 24 Ash JS, McCormack JL, Sittig DF, Wright A, McMullen C, Bates DW. Standard practices for computerized clinical decision support in community hospitals: a national survey. J Am Med Inform Assoc 2012; 19 (06) 980-987.
  • 25 Bright TJ, Wong A, Dhurjati R, Bristow E, Bastian L, Coeytaux RR, Samsa G, Hasselblad V, Williams JW, Musty MD, Wing L, Kendrick AS, Sanders GD, Lobach D. Effect of clinical decision-support systems: a systematic review. Ann Intern Med 2012; 157 (01) 29-43.
  • 26 Sochalski J, Jaarsma T, Krumholz HM, Laramee A, McMurray JJ, Naylor MD, Rich MW, Riegel B, Stewart S. What works in chronic care management: the case of heart failure. Health Aff 2009; 28 (Suppl. 01) 179-189.
  • 27 Phillips CO, Singa RM, Rubin HR, Jaarsma T. Complexity of program and clinical outcomes of heart failure disease management incorporating specialist nurse-led heart failure clinics. A meta-regression analysis. European journal of heart failure 2005; 7 (03) 333-341.
  • 28 de Bruin SR, Heijink R, Lemmens LC, Struijs JN, Baan CA. Impact of disease management programs on healthcare expenditures for patients with diabetes, depression, heart failure or chronic obstructive pulmonary disease: a systematic review of the literature. Health Policy 2011; 101 (02) 105-121.
  • 29 Nucifora G, Albanese MC, De Biaggio P, Caliandro D, Gregori D, Goss P, Miani D, Fresco C, Rossi P, Bulfoni A, Fioretti PM. Lack of improvement of clinical outcomes by a low-cost, hospital-based heart failure management programme. Journal of cardiovascular medicine 2006; 7 (08) 614-622.
  • 30 Savard LA, Thompson DR, Clark AM. A meta-review of evidence on heart failure disease management programs: the challenges of describing and synthesizing evidence on complex interventions. Trials 2011; 12: 194.
  • 31 Smith B, Forkner E, Zaslow B, Krasuski RA, Stajduhar K, Kwan M, Ellis R, Galbreath AD, Freeman GL. Disease management produces limited quality-of-life improvements in patients with congestive heart failure: evidence from a randomized trial in community-dwelling patients. Am J Manag Care 2005; 11 (11) 701-713.
  • 32 Feltner C, Jones C, Cené C, Zheng ZJ, Sueta C, Coker-Schwimmer E, Arvanitis M, Lohr K, Middleton J, Jonas D. Transitional Care Interventions To Prevent Readmissions for People With Heart Failure. Rockville, MD: Agency for Healthcare Research and Quality; 2014
  • 33 Borgatti SP, Foster PC. The Network Paradigm in Organizational Research: A Review and Typology. Journal of Management 2003; 29 (06) 991.
  • 34 Galbraith J. Designing Organizations: An Executive Briefing on Strategy,Structure, and Process. San Francisco, CA: Jossey-Bass; 1995
  • 35 Peikes D, Chen A, Schore J, Brown R. Effects of care coordination on hospitalization, quality of care, and health care expenditures among medicare beneficiaries: 15 randomized trials. JAMA 2009; 301 (06) 603-618.
  • 36 McClellan M, McKethan AN, Lewis JL, Roski J, Fisher ES. A National Strategy To Put Accountable Care Into Practice. Health Aff 2010; 29 (05) 982-990.
  • 37 Butler EN, Chawla N, Lund J, Harlan LC, Warren JL, Yabroff KR. Patterns of Colorectal Cancer Care in the United States and Canada: A Systematic Review. Journal of the National Cancer Institute Monographs 2013; 2013 (46) 13-35.
  • 38 Daly B, Olopade OI. A perfect storm: How tumor biology, genomics, and health care delivery patterns collide to create a racial survival disparity in breast cancer and proposed interventions for change. CA: A Cancer Journal for Clinicians 2015; 65 (03) 221-238.
  • 39 Lipscomb J, Yabroff KR, Hornbrook MC, Gigli A, Francisci S, Krahn M, Gatta G, Trama A, Ritzwoller DP, Durand-Zaleski I, Salloum R, Chawla N, Angiolini C, Crocetti E, Giusti F, Guzzinati S, Mezzetti M, Miccinesi G, Mariotto A. Comparing Cancer Care, Outcomes, and Costs Across Health Systems: Charting the Course. Journal of the National Cancer Institute Monographs 2013; 2013 (46) 124-130.
  • 40 Pater J, Rochon J, Parmar M, Selby P. Future research and methodological approaches. Annals of Oncology 2011; 22 (07) vii57-vii61.
  • 41 Ronksley PE, McKay JA, Kobewka DM, Mulpuru S, Forster AJ. Patterns of health care use in a high-cost inpatient population in Ottawa, Ontario: a retrospective observational study. CMAJ Open 2015; 3 (01) E111-E118.
  • 42 Selby P, Autier P. The impact of the process of clinical research on health service outcomes. Annals of Oncology 2011; 22 (07) vii5-vii9.
  • 43 Sundararajan V, Bohensky M, Moore G, Brand C, Lethborg C, Gold M, Murphy M, Collins A, Philip J. Mapping the patterns of care, the receipt of palliative care and the site of death for patients with malignant glioma. J Neurooncol 2014; 116 (01) 119-126.
  • 44 Unrau YA, Wells MA. Patterns of foster care service delivery. Children and Youth Services Review 2005; 27 (05) 511-531.
  • 45 Yabroff KR, Francisci S, Mariotto A, Mezzetti M, Gigli A, Lipscomb J. Advancing Comparative Studies of Patterns of Care and Economic Outcomes in Cancer: Challenges and Opportunities. Journal of the National Cancer Institute Monographs 2013; 2013 (46) 1-6.
  • 46 Walsh C, Hripcsak G. The effects of data sources, cohort selection, and outcome definition on a predictive model of risk of thirty-day hospital readmissions. Journal of Biomedical Informatics 2014; 52: 418-426.
  • 47 Carley KM. ORA A Toolkit for Dynamic Network Analysis and Visualization. In: Alhajj R, Rokne J. (editors) Encyclopedia of Social Network Analysis and Mining. New York, NY: Springer; 2014
  • 48 Wasserman S, Faust K. Social Network Analysis: Methods and Applications. Cambridge: Cambridge University Press; 1994
  • 49 Carillo J, Carillo V, Guimento R, Murcaria J, Leiman J. The New York-Presbyterian regional health collaborative: A three-year progress report. Health Aff 2014; 33 (11) 1985-1992.
  • 50 Cunningham FC, Ranmuthugala G, Plumb J, Georgiou A, Westbrook JI, Braithwaite J. Health professional networks as a vector for improving healthcare quality and safety: a systematic review. BMJ Quality & Safety 2012; 21 (03) 239-249.
  • 51 Porter SC, Forbes P, Feldman HA, Goldmann DA. Impact of patient-centered decision support on quality of asthma care in the emergency department. Pediatrics 2006; 117 (01) e33-42.
  • 52 Freeman LC. Centrality in social networks: Concept clarification. Social Networks 1979; 1: 215-239.
  • 53 Pollack CE, Weissman GE, Lemke KW, Hussey PS, Weiner JP. Patient Sharing Among Physicians and Costs of Care: A Network Analytic Approach to Care Coordination Using Claims Data. Journal of general internal medicine 2013; 28 (03) 459-465.

Correspondence to:

Jacqueline A Merrill, PhD, MPH, RN
Associate Professor of Nursing in Biomedical Informatics
Columbia University Medical Center
617 West 168th Street, Georgian 226
New York, New York 10034
Phone: 212 305 3194   

  • References

  • 1 McDonald K, Sundaram V, Bravata D, Lewis R. Closing the Quality Gap: A Critical Analysis of Quality Improvement Strategies No.7 ed. Vol. 7, Care Coordination. Rockville, MD: Agency for Healthcare Research and Quality 2007. p. 3, Definitions of Care Coordination and Related Terms.
  • 2 Institute of Medicine.. The Healthcare Imperative: Lowering Costs and Improving Outcomes: Workshop Series Summary. In: Yong PL, Saunders RS, Olsen LA. editors. Vol 3 Inefficiently Delivered Services, Roundtable on Evidence-Based Medicine. Washington, DC: National Academies Press; 2010
  • 3 Institute of Medicine.. Best Care at Lower Cost: The Path to Continuously Learning Health Care in America. Washington, DC: National Academy of Sciences; 2012
  • 4 Guterman S, Davis K, Schoenbaum S, Shih A. Using Medicare Payment Policy To Transform The Health System: A Framework For Improving Performance. Health Aff 2009; 28 (02) w238-w250.
  • 5 Landon BE, Keating NL, Barnett ML, Onnela JP, Paul S, O’Malley AJ, Keegan T, Christakis NA. Variation in patient-sharing networks of physicians across the United States. JAMA 2012; 308 (03) 265-273.
  • 6 National Quality Forum.. Effective Communication and Care Coordination [cited 2015 February 9]. Available from: http://www.qualityforum.org/Topics/Effective_Communication_and_Care_Coordination.aspx
  • 7 Agency for Healthcare Research and Quality (AHRQ).. National Strategy for Quality Improvement in Health Care. Rockville, MD: Department of Health and Human Services; 2011
  • 8 Asaro PV, Sheldahl AL, Char DM. Embedded guideline information without patient specificity in a commercial emergency department computerized order-entry system. Acad Emerg Med 2006; 13 (04) 452-458.
  • 9 Handler JA, Feied CF, Coonan K, Vozenilek J, Gillam M, Peacock PR, Sinert R, Smith MS. Computerized physician order entry and online decision support. Acad Emerg Med 2004; 11 (11) 1135-1141.
  • 10 Press MJ, Michelow MD, MacPhail LH. Care coordination in accountable care organizations: moving beyond structure and incentives. Am J Manag Care 2012; 18 (12) 778-780.
  • 11 Agency for Healthcare Research and Quality (AHRQ).. Closing the quality gap: A critical analysis of quality improvement strategies. Rockville, MD.: AHRQ; 2007
  • 12 Heidenreich PA, Albert NM, Allen LA, Bluemke DA, Butler J, Fonarow GC, Ikonomidis JS, Khavjou O, Konstam MA, Maddox TM, Nichol G, Pham M, Pina IL, Trogdon JG. Forecasting the Impact of Heart Failure in the United States: A Policy Statement From the American Heart Association. Circ Heart Fail 2013; 6 (03) 606-619.
  • 13 Takeda A, Taylor SJ, Taylor RS, Khan F, Krum H, Underwood M. Clinical service organisation for heart failure. Cochrane Database Syst Rev 2012; 9: CD002752.
  • 14 Dharmarajan K, Hsieh AF, Lin Z, Bueno H, Ross JS, Horwitz LI, Barreto-Filho JA, Kim N, Bernheim SM, Suter LG, Drye EE, Krumholz HM. Diagnoses and timing of 30-day readmissions after hospitalization for heart failure, acute myocardial infarction, or pneumonia. JAMA 2013; 309 (04) 355-363.
  • 15 Krumholz HM, Merrill AR, Schone EM, Schreiner GC, Chen J, Bradley EH, Wang Y, Wang Y, Lin Z, Straube BM, Rapp MT, Normand SL, Drye EE. Patterns of hospital performance in acute myocardial infarction and heart failure 30-day mortality and readmission. Circulation Cardiovascular quality and outcomes 2009; 2 (05) 407-413.
  • 16 Jencks SF, Williams MV, Coleman EA. Rehospitalizations among patients in the Medicare fee-for-service program. The New England journal of medicine 2009; 360 (14) 1418-1428.
  • 17 Ross JS, Chen J, Lin Z, Bueno H, Curtis JP, Keenan PS, Normand SL, Schreiner G, Spertus JA, Vidan MT, Wang Y, Wang Y, Krumholz HM. Recent national trends in readmission rates after heart failure hospitalization. Circ Heart Fail 2010; 3 (01) 97-103.
  • 18 Au AG, McAlister FA, Bakal JA, Ezekowitz J, Kaul P, van Walraven C. Predicting the risk of unplanned readmission or death within 30 days of discharge after a heart failure hospitalization. American heart journal 2012; 164 (03) 365-372.
  • 19 Coffey RM, Misra A, Barrett M, Andrews RM, Mutter R, Moy E. Congestive heart failure: who is likely to be readmitted?. Medical care research and review MCRR 2012; 69 (05) 602-616.
  • 20 Wallmann R, Llorca J, Gomez-Acebo I, Ortega AC, Roldan FR, Dierssen-Sotos T. Prediction of 30-day cardiac-related-emergency-readmissions using simple administrative hospital data. International journal of cardiology 2013; 164 (02) 193-200.
  • 21 Ross JS, Mulvey GK, Stauffer B, Patlolla V, Bernheim SM, Keenan PS, Krumholz HM. Statistical models and patient predictors of readmission for heart failure: a systematic review. Arch Intern Med 2008; 168 (13) 1371-1386.
  • 22 Gwadry-Sridhar FH, Flintoft V, Lee DS, Lee H, Guyatt GH. A systematic review and meta-analysis of studies comparing readmission rates and mortality rates in patients with heart failure. Arch Intern Med 2004; 164 (21) 2315-2320.
  • 23 Barnett ML, Christakis NA, O’Malley J, Onnela JP, Keating NL, Landon BE. Physician patient-sharing networks and the cost and intensity of care in US hospitals. Med Care 2012; 50 (02) 152-160.
  • 24 Ash JS, McCormack JL, Sittig DF, Wright A, McMullen C, Bates DW. Standard practices for computerized clinical decision support in community hospitals: a national survey. J Am Med Inform Assoc 2012; 19 (06) 980-987.
  • 25 Bright TJ, Wong A, Dhurjati R, Bristow E, Bastian L, Coeytaux RR, Samsa G, Hasselblad V, Williams JW, Musty MD, Wing L, Kendrick AS, Sanders GD, Lobach D. Effect of clinical decision-support systems: a systematic review. Ann Intern Med 2012; 157 (01) 29-43.
  • 26 Sochalski J, Jaarsma T, Krumholz HM, Laramee A, McMurray JJ, Naylor MD, Rich MW, Riegel B, Stewart S. What works in chronic care management: the case of heart failure. Health Aff 2009; 28 (Suppl. 01) 179-189.
  • 27 Phillips CO, Singa RM, Rubin HR, Jaarsma T. Complexity of program and clinical outcomes of heart failure disease management incorporating specialist nurse-led heart failure clinics. A meta-regression analysis. European journal of heart failure 2005; 7 (03) 333-341.
  • 28 de Bruin SR, Heijink R, Lemmens LC, Struijs JN, Baan CA. Impact of disease management programs on healthcare expenditures for patients with diabetes, depression, heart failure or chronic obstructive pulmonary disease: a systematic review of the literature. Health Policy 2011; 101 (02) 105-121.
  • 29 Nucifora G, Albanese MC, De Biaggio P, Caliandro D, Gregori D, Goss P, Miani D, Fresco C, Rossi P, Bulfoni A, Fioretti PM. Lack of improvement of clinical outcomes by a low-cost, hospital-based heart failure management programme. Journal of cardiovascular medicine 2006; 7 (08) 614-622.
  • 30 Savard LA, Thompson DR, Clark AM. A meta-review of evidence on heart failure disease management programs: the challenges of describing and synthesizing evidence on complex interventions. Trials 2011; 12: 194.
  • 31 Smith B, Forkner E, Zaslow B, Krasuski RA, Stajduhar K, Kwan M, Ellis R, Galbreath AD, Freeman GL. Disease management produces limited quality-of-life improvements in patients with congestive heart failure: evidence from a randomized trial in community-dwelling patients. Am J Manag Care 2005; 11 (11) 701-713.
  • 32 Feltner C, Jones C, Cené C, Zheng ZJ, Sueta C, Coker-Schwimmer E, Arvanitis M, Lohr K, Middleton J, Jonas D. Transitional Care Interventions To Prevent Readmissions for People With Heart Failure. Rockville, MD: Agency for Healthcare Research and Quality; 2014
  • 33 Borgatti SP, Foster PC. The Network Paradigm in Organizational Research: A Review and Typology. Journal of Management 2003; 29 (06) 991.
  • 34 Galbraith J. Designing Organizations: An Executive Briefing on Strategy,Structure, and Process. San Francisco, CA: Jossey-Bass; 1995
  • 35 Peikes D, Chen A, Schore J, Brown R. Effects of care coordination on hospitalization, quality of care, and health care expenditures among medicare beneficiaries: 15 randomized trials. JAMA 2009; 301 (06) 603-618.
  • 36 McClellan M, McKethan AN, Lewis JL, Roski J, Fisher ES. A National Strategy To Put Accountable Care Into Practice. Health Aff 2010; 29 (05) 982-990.
  • 37 Butler EN, Chawla N, Lund J, Harlan LC, Warren JL, Yabroff KR. Patterns of Colorectal Cancer Care in the United States and Canada: A Systematic Review. Journal of the National Cancer Institute Monographs 2013; 2013 (46) 13-35.
  • 38 Daly B, Olopade OI. A perfect storm: How tumor biology, genomics, and health care delivery patterns collide to create a racial survival disparity in breast cancer and proposed interventions for change. CA: A Cancer Journal for Clinicians 2015; 65 (03) 221-238.
  • 39 Lipscomb J, Yabroff KR, Hornbrook MC, Gigli A, Francisci S, Krahn M, Gatta G, Trama A, Ritzwoller DP, Durand-Zaleski I, Salloum R, Chawla N, Angiolini C, Crocetti E, Giusti F, Guzzinati S, Mezzetti M, Miccinesi G, Mariotto A. Comparing Cancer Care, Outcomes, and Costs Across Health Systems: Charting the Course. Journal of the National Cancer Institute Monographs 2013; 2013 (46) 124-130.
  • 40 Pater J, Rochon J, Parmar M, Selby P. Future research and methodological approaches. Annals of Oncology 2011; 22 (07) vii57-vii61.
  • 41 Ronksley PE, McKay JA, Kobewka DM, Mulpuru S, Forster AJ. Patterns of health care use in a high-cost inpatient population in Ottawa, Ontario: a retrospective observational study. CMAJ Open 2015; 3 (01) E111-E118.
  • 42 Selby P, Autier P. The impact of the process of clinical research on health service outcomes. Annals of Oncology 2011; 22 (07) vii5-vii9.
  • 43 Sundararajan V, Bohensky M, Moore G, Brand C, Lethborg C, Gold M, Murphy M, Collins A, Philip J. Mapping the patterns of care, the receipt of palliative care and the site of death for patients with malignant glioma. J Neurooncol 2014; 116 (01) 119-126.
  • 44 Unrau YA, Wells MA. Patterns of foster care service delivery. Children and Youth Services Review 2005; 27 (05) 511-531.
  • 45 Yabroff KR, Francisci S, Mariotto A, Mezzetti M, Gigli A, Lipscomb J. Advancing Comparative Studies of Patterns of Care and Economic Outcomes in Cancer: Challenges and Opportunities. Journal of the National Cancer Institute Monographs 2013; 2013 (46) 1-6.
  • 46 Walsh C, Hripcsak G. The effects of data sources, cohort selection, and outcome definition on a predictive model of risk of thirty-day hospital readmissions. Journal of Biomedical Informatics 2014; 52: 418-426.
  • 47 Carley KM. ORA A Toolkit for Dynamic Network Analysis and Visualization. In: Alhajj R, Rokne J. (editors) Encyclopedia of Social Network Analysis and Mining. New York, NY: Springer; 2014
  • 48 Wasserman S, Faust K. Social Network Analysis: Methods and Applications. Cambridge: Cambridge University Press; 1994
  • 49 Carillo J, Carillo V, Guimento R, Murcaria J, Leiman J. The New York-Presbyterian regional health collaborative: A three-year progress report. Health Aff 2014; 33 (11) 1985-1992.
  • 50 Cunningham FC, Ranmuthugala G, Plumb J, Georgiou A, Westbrook JI, Braithwaite J. Health professional networks as a vector for improving healthcare quality and safety: a systematic review. BMJ Quality & Safety 2012; 21 (03) 239-249.
  • 51 Porter SC, Forbes P, Feldman HA, Goldmann DA. Impact of patient-centered decision support on quality of asthma care in the emergency department. Pediatrics 2006; 117 (01) e33-42.
  • 52 Freeman LC. Centrality in social networks: Concept clarification. Social Networks 1979; 1: 215-239.
  • 53 Pollack CE, Weissman GE, Lemke KW, Hussey PS, Weiner JP. Patient Sharing Among Physicians and Costs of Care: A Network Analytic Approach to Care Coordination Using Claims Data. Journal of general internal medicine 2013; 28 (03) 459-465.