DOI:
        10.1055/s-00000077
      
      
        Seminars in Thrombosis and Hemostasis
      
      
        
          
            Issue 02 ·
           Volume 27 ·
            2001
            
          
           DOI: 10.1055/s-002-3189 
          
          
          
        
        
  
  
    
  
  
  
    
  
  
  
    
  
  
  
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
      
    
  
    
      
    
  
    
      
    
  
    
      
    
  
    
      
    
  
    
      
    
  
    
      
    
  
    
      
    
  
    
      
    
  
    
      
    
  
    
      
    
  
    
      
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
  
    
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
        
          
            
              
              
              
                
                  
                    
                    
                      
                          
                          
                            
                             
                          
                          
                          
                          
                            
                          
                          
                            
                          
                          
                          
                            
                          
                          
                          
                          
  
    
      
        067
      
    
  
  
  
    
    
    
      
    
    
      
        
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
          
          
            
              
              Okada, Yoshichika; 
              
            
          
            
              
              Asahina, Toshihiko; 
              
            
          
            
              
              Kobayashi, Takao; 
              
            
          
            
              
              Goto, Junko; 
              
            
          
            
              
              Terao, Toshihiko: 
              
            
          
      
    
    
    
    
      
      
        
      
      
        
        
        
      
    
    
      
    
    
    
    
    
    
    
      
    
   
                      
                          
                          
                          
                          
                          
                            
                          
                          
                            
                          
                          
                          
                          
                          
                          
  
    
      
        079
      
    
  
  
  
    
    
    
      
    
    
      
        
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
          
          
            
              
              Khatun, Selina; 
              
            
          
            
              
              Kobayashi, Takao; 
              
            
          
            
              
              Belayet, Hossain; 
              
            
          
            
              
              Sumimoto, Kazuhiro; 
              
            
          
            
              
              Iwaki, Takayuki; 
              
            
          
            
              
              Kanayama, Naohiro: 
              
            
          
      
    
    
    
    
      
      
        
      
      
        
        
        
      
    
    
      
    
    
    
    
    
    
    
      
    
   
                      
                          
                          
                          
                          
                          
                            
                          
                          
                            
                          
                          
                          
                          
                          
                          
  
    
      
        087
      
    
  
  
  
    
    
    
      
    
    
      
        
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
          
          
            
              
              Nishiguchi, Tomizo; 
              
            
          
            
              
              Matsuyama, Kaoru; 
              
            
          
            
              
              Kobayashi, Takao; 
              
            
          
            
              
              Kanayama, Naohiro; 
              
            
          
            
              
              Terao, Toshihiko; 
              
            
          
            
              
              Maeda, Makoto; 
              
            
          
            
              
              Ibara, Satoshi: 
              
            
          
      
    
    
    
    
      
      
        
      
      
        
        
        
      
    
    
      
    
    
    
    
    
    
    
      
    
   
                      
                          
                          
                          
                          
                          
                            
                          
                          
                            
                          
                          
                          
                          
                          
                          
  
    
      
        093
      
    
  
  
  
    
    
    
      
    
    
      
        
          
            
              
            
          
            
              
            
          
            
              
            
          
          
          
            
              
              Suzuki, Shigenori; 
              
            
          
            
              
              Iwata, Ginko; 
              
            
          
            
              
              Sutor, Anton H.: 
              
            
          
      
    
    
    
    
      
      
        
      
      
        
        
        
      
    
    
      
    
    
    
    
    
    
    
      
    
   
                      
                          
                          
                          
                          
                          
                            
                          
                          
                            
                          
                          
                          
                          
                          
                          
  
    
      
        099
      
    
  
  
  
    
    
    
      
    
    
      
        
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
          
          
            
              
              Shu, Fang; 
              
            
          
            
              
              Sugimura, Motoi; 
              
            
          
            
              
              Kobayashi, Hiroshi; 
              
            
          
            
              
              Kobayashi, Takao; 
              
            
          
            
              
              Kanayama, Naohiro: 
              
            
          
      
    
    
    
    
      
      
        
      
      
        
        
        
      
    
    
      
    
    
    
    
    
    
    
      
    
   
                      
                          
                          
                          
                          
                          
                            
                          
                          
                            
                          
                          
                          
                          
                          
                          
  
    
      
        107
      
    
  
  
  
    
    
    
      
    
    
      
        
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
          
          
            
              
              Sugimura, Motoi; 
              
            
          
            
              
              Ohashi, Ryouta; 
              
            
          
            
              
              Kobayashi, Takao; 
              
            
          
            
              
              Kanayama, Naohiro: 
              
            
          
      
    
    
    
    
      
      
        
      
      
        
        
        
      
    
    
      
    
    
    
    
    
    
    
      
    
   
                      
                          
                          
                          
                          
                          
                            
                          
                          
                            
                          
                          
                          
                          
                          
                          
  
    
      
        115
      
    
  
  
  
    
    
    
      
    
    
      
        
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
          
          
            
              
              Matsuura, Toshiki; 
              
            
          
            
              
              Kobayashi, Takao; 
              
            
          
            
              
              Asahina, Toshihiko; 
              
            
          
            
              
              Kanayama, Naohiro; 
              
            
          
            
              
              Terao, Toshihiko: 
              
            
          
      
    
    
    
    
      
      
        
      
      
        
        
        
      
    
    
      
    
    
    
    
    
    
    
      
    
   
                      
                          
                          
                          
                          
                          
                            
                          
                          
                            
                          
                          
                          
                          
                          
                          
  
    
      
        121
      
    
  
  
  
    
    
    
      
    
    
      
        
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
          
          
            
              
              Yamada, Hideto; 
              
            
          
            
              
              Kato, Emi H.; 
              
            
          
            
              
              Kobashi, Gen; 
              
            
          
            
              
              Ebina, Yasuhiko; 
              
            
          
            
              
              Shimada, Shigeki; 
              
            
          
            
              
              Morikawa, Mamoru; 
              
            
          
            
              
              Yamada, Takahiro; 
              
            
          
            
              
              Sakuragi, Noriaki; 
              
            
          
            
              
              Fujimoto, Seiichiro: 
              
            
          
      
    
    
    
    
      
      
        
      
      
        
        
        
      
    
    
      
    
    
    
    
    
    
    
      
    
   
                      
                          
                          
                          
                          
                          
                            
                          
                          
                            
                          
                          
                          
                          
                          
                          
  
    
      
        131
      
    
  
  
  
    
    
    
      
    
    
      
        
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
          
          
            
              
              Kobayashi, Takao; 
              
            
          
            
              
              Tokunaga, Naoki; 
              
            
          
            
              
              Isoda, Haruo; 
              
            
          
            
              
              Kanayama, Naohiro; 
              
            
          
            
              
              Terao, Toshihiko: 
              
            
          
      
    
    
    
    
      
      
        
      
      
        
        
        
      
    
    
      
    
    
    
    
    
    
    
      
    
   
                      
                          
                          
                          
                          
                          
                            
                          
                          
                            
                          
                          
                          
                          
                          
                          
  
    
      
        137
      
    
  
  
  
    
    
    
      
    
    
      
        
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
          
          
            
              
              Kobayashi, Takao; 
              
            
          
            
              
              Tokunaga, Naoki; 
              
            
          
            
              
              Sugimura, Motoi; 
              
            
          
            
              
              Kanayama, Naohiro; 
              
            
          
            
              
              Terao, Toshihiko: 
              
            
          
      
    
    
    
    
      
      
        
      
      
        
        
        
      
    
    
      
    
    
    
    
    
    
    
      
    
   
                      
                          
                          
                          
                          
                          
                            
                          
                          
                            
                          
                          
                          
                          
                          
                          
  
    
      
        143
      
    
  
  
  
    
    
    
      
    
    
      
        
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
          
          
            
              
              Kobashi, Gen; 
              
            
          
            
              
              Shido, Koichi; 
              
            
          
            
              
              Hata, Akira; 
              
            
          
            
              
              Yamada, Hideto; 
              
            
          
            
              
              Kato, Emi-Hirayama; 
              
            
          
            
              
              Kanamori, Masao; 
              
            
          
            
              
              Fujimoto, Seiichiro; 
              
            
          
            
              
              Kondo, Kiyotaro: 
              
            
          
      
    
    
    
    
      
      
        
      
      
        
        
        
      
    
    
      
    
    
    
    
    
    
    
      
    
   
                      
                          
                          
                          
                          
                          
                            
                          
                          
                            
                          
                          
                          
                          
                          
                          
  
    
      
        149
      
    
  
  
  
    
    
    
      
    
    
      
        
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
          
          
            
              
              Adachi, Tomoko; 
              
            
          
            
              
              Hashiguchi, Kazunari; 
              
            
          
            
              
              Arai, Yoshimi; 
              
            
          
            
              
              Ohta, Hiroaki: 
              
            
          
      
    
    
    
    
      
      
        
      
      
        
        
        
      
    
    
      
    
    
    
    
    
    
    
      
    
   
                      
                          
                          
                          
                          
                          
                            
                          
                          
                            
                          
                          
                          
                          
                          
                          
  
    
      
        155
      
    
  
  
  
    
    
    
      
    
    
      
        
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
          
          
            
              
              Iwaki, Takayuki; 
              
            
          
            
              
              Mastushita, Tadashi; 
              
            
          
            
              
              Kobayashi, Takao; 
              
            
          
            
              
              Yamamoto, Yukako; 
              
            
          
            
              
              Nomura, Yuka; 
              
            
          
            
              
              Kagami, Kazuo; 
              
            
          
            
              
              Nakayama, Takayuki; 
              
            
          
            
              
              Sugiura, Isamu; 
              
            
          
            
              
              Kojima, Tetsuhito; 
              
            
          
            
              
              Takamatsu, Junki; 
              
            
          
            
              
              Kanayama, Naohiro; 
              
            
          
            
              
              Saito, Hidehiko: 
              
            
          
      
    
    
    
    
      
      
        
      
      
        
        
        
      
    
    
      
    
    
    
    
    
    
    
      
    
   
                      
                          
                          
                          
                          
                          
                            
                          
                          
                            
                          
                          
                          
                          
                          
                          
  
    
      
        161
      
    
  
  
  
    
    
    
      
    
    
      
        
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
          
          
            
              
              Kobayashi, Takao; 
              
            
          
            
              
              Terao, Toshihiko; 
              
            
          
            
              
              Maki, Masahiro; 
              
            
          
            
              
              Ikenoue, Tsuyomu: 
              
            
          
      
    
    
    
    
      
      
        
      
      
        
        
        
      
    
    
      
    
    
    
    
    
    
    
      
    
   
                      
                          
                          
                          
                          
                          
                            
                          
                          
                            
                          
                          
                          
                          
                          
                          
  
    
      
        169
      
    
  
  
  
    
    
    
      
    
    
      
        
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
          
          
            
              
              Knöfler, Ralf; 
              
            
          
            
              
              Dinger, Jürgen; 
              
            
          
            
              
              Kabus, Maria; 
              
            
          
            
              
              Müller, Diane; 
              
            
          
            
              
              Lauterbach, Ingrid; 
              
            
          
            
              
              Rupprecht, Edgar; 
              
            
          
            
              
              Taut-Sack, Heike; 
              
            
          
            
              
              Weissbach, Gerhard: