Misteltherapie bei Equinen Sarkoiden – klinische Studien mit Viscum album

Das Equine Sarkoid ist der häufigste Hauttumor beim Pferd und stellt eine therapeutische Herausforderung dar. Mistelpräparate wie Iscador werden als alternative Behandlungsoption diskutiert. Studien zeigen vielversprechende Ergebnisse.

Publikationsverlauf

Artikel online veröffentlicht:
12. November 2025

• Literatur

• 1 Nasir L, Campo MS. Bovine papillomaviruses: their role in the aetiology of cutaneous tumours of bovids and equids. Vet Dermatol 2008; 19: 243-254
• 2 Staiger EA, Tseng CT, Miller D. et al Host genetic influence on papillomavirus-induced tumors in the horse. Int J Cancer 2016; 139: 784-792
• 3 Bergvall KE. Sarcoids. Vet Clin N Am Equine Pract 2013; 29: 657-671
• 4 Ostermann T, Appelbaum S, Poier D. et al A systematic review and meta-analysis on the survival of cancer patients treated with a fermented Viscum album L. extract (Iscador): an update of findings. Complement Med Res 2020; 27: 260-271
• 5 Harmsma M, Ummelen M, Dignef W. et al Effects of mistletoe (Viscum album L.) extracts Iscador on cell cycle and survival of tumor cells. Arzneimittelforschung 2006; 56: 474-482
• 6 Pryme IF, Bardocz S, Pusztai A, Ewen SWB. Suppression of growth of tumour cell lines in vitro and tumours in vivo by mistletoe lectins. Histol Histopathol 2006; 21: 285-299
• 7 Eggenschwiler J, von Balthazar L, Stritt B. et al Mistletoe lectin is not the only cytotoxic component in fermented preparations of Viscum album from white fir (Abies pectinata). BMC Complement Altern Med 2007; 7: 14
• 8 Heinzerling L, von Baehr V, Liebenthal C. et al Immunologic effector mechanisms of a standardized mistletoe extract on the function of human monocytes and lymphocytes in vitro, ex vivo, and in vivo. J Clin Immunol 2006; 26: 347-359
• 9 Elluru SR, Duong Van Huyen JP, Delignat S. et al Antiangiogenic properties of Viscum album extracts are associated with endothelial cytotoxicity. Anticancer Res 2009; 29: 2945-2950 http://ar.iiarjournals.org/content/29/8/2945.full.pdf
• 10 Christen-Clottu O, Klocke P, Burger D. et al Treatment of clinically diagnosed equine sarcoid with a mistletoe extract (Viscum album austriacus). J Vet Intern Med 2010; 24(6):1483–1489.
• 11 Christen-Clottu U, Reif MOB. Fallserie zur oralen Verwendung eines Mistelextraktes (Viscum album L.) beim equinen Sarkoid. Zeitschrift für Phytotherapie 2022; 43: P61
• 12 Beermann A, Clottu O, Reif M. et al A randomized placebo-controlled double-blinded study comparing oral and subcutaneous administration of mistletoe extract for the treatment of equine sarcoid disease. J Vet Intern Med 2024; 1-10
• 13 Lyu SY, Park WB. Transport of mistletoe lectin by M cells in human intestinal follicle-associated epithelium (FAE) in vitro. Arch Pharm Res 2008; 31: 1613-1621
• 14 Lyu SY, Park WB. Mistletoe lectin transport by M-cells in follicleassociated epithelium (FAE) and IL-12 secretion in dendritic cells situated below FAE in vitro. Arch Pharm Res 2010; 33: 1433-1441
• 15 Clark MA, Hirst BH, Jepson MA. Lectin-mediated mucosal delivery of drugs and microparticles. Adv Drug Deliv Rev 2000; 43: 207-223
• 16 Yousefi M, Naderi Farsani M, Ghafarifarsani H. et al The effects of dietary supplementation of mistletoe (Viscum album) extract on the growth performance, antioxidant, and innate, immune responses of rainbow trout (Oncorhynchus mykiss. Aquaculture 2021; 536: 736385
• 17 Pryme IF, Bardocz S, Pusztai A, Ewen SWB. Dietary mistletoe lectin supplementation and reduced growth of a murine non-Hodgkin lymphoma. Histol Histopathol 2002; 17: 261-271