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DOI: 10.1055/s-0028-1091759
© 1973 by Thieme Medical Publishers, Inc.
Ontogenetic Development of Bioelectrical Activity of the Epileptogenic Focus in Rat Neocortex
Publication History
1973
1973
Publication Date:
18 November 2008 (online)
The bioelectrical activity of an epileptogenic focus formed by applying penicillin to the sensorimotor area of the cerebral cortex was studied in 76 male rats aged 3–29 days. A focus was formed in all the animals, but its discharges altered during development. Primary focal discharges acquired a mature shape and duration at the age of 12 days. No after-discharge was yet present in this phase, however, and it was not recorded in its definitive form until the 24th day. A projected discharge, recorded in the symmetrical site of the contralateral hemisphere, was present for the first time in 5-day-old rats, but up to the 7th day it was inconstant. This interhemispheric transmission underwent distinct development between the 7th and 14th day after birth and at 14 days the discharge of the “mirror” focus was practically no different from the findings in adult animals. The projected discharge in the occipital region of the “primary” hemisphere attained its definitive shape on the 24th day.
Cerebral cortex - Epileptogenic focus - Propagation of discharges - Ontogenesis