Detection of immunoreactive parathyroid hormone-related protein in human cerebrospinal fluid

G. Bühler; S. Balabanova; S. Milowski; J. Rosenthal; G. Antoniadis; K. Mohr; H. P. Richter

doi:10.1055/s-0029-1211775

Experimental and Clinical Endocrinology & Diabetes, Inhaltsverzeichnis

Exp Clin Endocrinol Diabetes 1997; 105(6): 336-340
DOI: 10.1055/s-0029-1211775

Original

Detection of immunoreactive parathyroid hormone-related protein in human cerebrospinal fluid

G. Bühler¹ , S. Balabanova¹ , S. Milowski¹ , J. Rosenthal¹ , G. Antoniadis² , K. Mohr² , H. P. Richter²

¹Section Pharmacotherapy, University of Ulm, Ulm, Germany
²Department of Neurosurgery, University of Ulm, Günzburg, Germany

Abstract

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Summary

Immunoreactive parathyroid hormone-related protein (PTH-rP) was measured in simultaneously obtained cerebrospinal fluid (CSF) and plasma from 51 patients suspected of suffering from a prolapsed intervertebral disc. Endocrine or psychiatric diseases were excluded. In addition, immunoreactive parathyroid hormone (PTH) in the CSF samples was measured. Both, PTH-rP and PTH were assayed by immunoradiometric assay. The results indicate the presence of both, PTH-rP and PTH in CSF The following concentrations (mean values ± SD) were found: PTH-rP (pmol/1) in CSF without pleocytosis (n = 17) 0,432 ± 0.157, with pleocytosis (n = 34) 0.654 ± 0.675; in plasma (pmol/1) 54.1 ± 14.632; PTH (nmol/1) in CSF without pleocytosis (n = 17) 0.454 ± 0.099, with pleocytosis (n = 34) 0.437 ± 0.140, and in plasma 4.272 ± 0.794. The concentrations of both, PTH-rP and PTH, in CSF with and without pleocytosis were not significantly different. No correlation was found between PTH-rP and PTH values. The present study demonstrated PTH-rP as a normal constituent in human CSF.

Key words

Parathyroid hormone-related protein - human CSF

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