Selenium Levels in Patients with Autoimmune Thyroiditis and Controls in Lower Austria

Abstract

Autoimmune thyroiditis (AIT) is one of the most common autoimmune diseases; genetic as well as environmental factors contribute to its pathogenesis. The thyroid is the organ with the highest selenium content per unit weight. Selenium status appears to have an impact on the development of thyroid pathologies. We investigated a possible difference of selenium serum levels as a marker of nutritional selenium supply between patients with AIT in central Lower Austria and a matched group of healthy persons living in the same region. Selenium serum levels in the patients with AIT were 98.0±15.6 μg/l. A significant difference to the matched group of normal persons, whose selenium serum levels were 103.2±12.4 μg/l, could not be detected by the t-test (p>0.05). We considered the serum selenium levels to be indicators of selenium supply (by alimentation). A serum level of 120–160 μg/l of selenium represents the normal range. According to this, most patients and control persons showed mild to moderate selenium deficiency (80–120 μg/l selenium). Although our data present slightly higher selenium levels in normal persons than in patients with AIT, this weak and statistically insignificant trend is not sufficient to support the conclusion of a link between inadequate selenium supply and autoimmune thyroid disease.

Key words

selenium - autoimmune thyroiditis - Lower Austria

• References

• 1 Gärtner R, Gasnier BC, Dietrich JW, Krebs B, Angstwurm MW. Selenium supplementation in patients with autoimmune thyroiditis decreases thyroid peroxidase antibodies concentrations. J Clin Endocrinol Metab 2002; 87: 1687-1691
• 2 Jabrocka-Hybel A, Skalniak A, Piątkowski J, Pach D, Hubalewska-Dydejczyk A. How far are we from understanding the genetic basis of Hashimoto’s thyroiditis?. Int Rev Immunol 2013; 32: 337-354
• 3 Weetman A. A hundred years of Hashimotos thyroiditis. Thyroid 2013; 23: 135-136
• 4 Schomburg L. Selenium, selenoproteins and the thyroid gland: interactions in health and disease. Nat Rev Endocrinol 2011; 8: 160-171
• 5 Drutel A, Archambeaud F, Caron P. Selenium and the thyroid gland: more good news for clinicians. Clin Endocrinol (Oxf) 2013; 78: 155-164
• 6 Duntas LH, Mantzou E, Koutras DA. Effects of a six month treatment with selenomethionine in patients with autoimmune thyroiditis. Eur J Endocrinol 2003; 148: 389-393
• 7 Bacić Vrca V, Skreb F, Cepelak I, Mayer L. Supplementation with antioxidants in the treatment of Graves’ disease: the effect on the extracellular antioxidative parameters. Acta Pharm 2004; 54: 79-89
• 8 Weeks BS, Hanna MS, Cooperstein D. Dietary selenium and selenoprotein function. Med Sci Monit 2012; 18: RA127-RA132
• 9 Johnson CC, Fordyce FM, Rayman MP. Symposium on ‛Geographical and geological influences on nutrition’: Factors controlling the distribution of selenium in the environment and their impact on health and nutrition. Proc Nutr Soc 2010; 69: 119-132
• 10 Schomburg L, Schweizer U, Holtmann B, Flohé L, Sendtner M, Köhrle J. Gene disruption discloses role of selenoprotein P in selenium delivery to target tissues. Biochem J 2003; 370: 397-402
• 11 Selenase® , In: Austria Codex (Österreichischer Apothekerverband, ed.). Wien: Österreichische Apotheker-Verlagsgesellschaft m.b.H; 2012. (UID: ATU14900008)
• 12 Sturniolo G, Mesa J. Selenium supplementation and autoimmune thyroid diseases. Endocrinol Nutr 2013; 60: 423-426
• 13 Navarro-Alarcon M, Cabrera-Vique C. Selenium in food and the human body: a review. Sci Total Environ 2008; 400: 115-141
• 14 Moreno-Reyes R, Suetens C, Mathieu F, Begaux F, Zhu D, Rivera MT, Boelaert M, Nève J, Perlmutter N, Vanderpas J. Kashin-Beck osteoarthropathy in rural Tibet in relation to selenium and iodine status. N Engl J Med 1998; 339: 1112-1120
• 15 Duntas LH. Selenium and the thyroid: a close-knit connection. J Clin Endocrinol Metab 2010; 95: 5180-5188
• 16 Rasmussen LB, Schomburg L, Köhrle J, Pedersen IB, Hollenbach B, Hög A, Ovesen L, Perrild H, Laurberg P. Selenium status, thyroid volume, and multiple nodule formation in an area with mild iodine deficiency. Eur J Endocrinol 2011; 164: 585-590
• 17 Karanikas G, Schuetz M, Kontur S, Duan H, Kommata S, Schoen R, Antoni A, Kletter K, Dudczak R, Willheim M. No immunological benefit of selenium in consecutive patients with autoimmune thyroiditis. Thyroid 2008; 18: 7-12
• 18 Bonfig W, Gärtner R, Schmidt H. Selenium supplementation does not decrease thyroid peroxidase antibody concentration in children and adolescents with autoimmune thyroiditis. ScientificWorldJournal 2010; 10: 990-996
• 19 Pestitschek M, Sonneck-Koenne C, Zakavi SR, Li S, Knoll P, Mirzaei S. Selenium intake and selenium blood levels: a novel food frequency questionnaire. Wien Klin Wochenschr 2013; 125: 160-164
• 20 Bülow Pedersen I, Knudsen N, Carlé A, Schomburg L, Köhrle J, Jørgensen T, Rasmussen LB, Ovesen L, Laurberg P. Serum selenium is low in newly diagnosed Graves’ disease: a population-based study. Clin Endocrinol (Oxf) 2013; 79: 584-590