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Horm Metab Res 2018; 50(02): 117-123
DOI: 10.1055/s-0043-124435
Endocrine Care
© Georg Thieme Verlag KG Stuttgart · New York

Associations of TNFRSF1A Polymorphisms with Autoimmune Thyroid Diseases: A Case-Control Study

Xiao-Qing Shao
1   Department of Endocrinology, Jinshan Hospital of Fudan University, Jinshan District, Shanghai, China
,
Xiao-Lian Ding
2   Department of Nephrology and Endocrinology, Weinan Central Hospital, Weinan, China
,
Kaida Mu
3   Department of Endocrinology, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Pudong New District, Shanghai, China
,
Xuan Wang
1   Department of Endocrinology, Jinshan Hospital of Fudan University, Jinshan District, Shanghai, China
,
Xiao-Fei An
1   Department of Endocrinology, Jinshan Hospital of Fudan University, Jinshan District, Shanghai, China
,
Qiu-Ming Yao
1   Department of Endocrinology, Jinshan Hospital of Fudan University, Jinshan District, Shanghai, China
,
Ling Li
1   Department of Endocrinology, Jinshan Hospital of Fudan University, Jinshan District, Shanghai, China
,
Qian Li
1   Department of Endocrinology, Jinshan Hospital of Fudan University, Jinshan District, Shanghai, China
,
Rong-Hua Song
1   Department of Endocrinology, Jinshan Hospital of Fudan University, Jinshan District, Shanghai, China
,
Shuang-tao He
1   Department of Endocrinology, Jinshan Hospital of Fudan University, Jinshan District, Shanghai, China
,
Jian Xu
1   Department of Endocrinology, Jinshan Hospital of Fudan University, Jinshan District, Shanghai, China
,
Jin-An Zhang
1   Department of Endocrinology, Jinshan Hospital of Fudan University, Jinshan District, Shanghai, China
› Author Affiliations
Further Information

Publication History

received 09 June 2017

accepted 04 December 2017

Publication Date:
05 February 2018 (online)

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Abstract

Previous studies have shown associations of polymorphisms in the tumor necrosis factor (TNF) receptor super family member 1A (TNFRSF1A) gene with several groups of inflammatory and autoimmune related diseases, but associations of TNFRSF1A polymorphisms with autoimmune thyroid diseases (AITD), mainly including two sub-types of Hashimoto’s thyroiditis (HT) and Graves’ disease (GD), in the Chinese Han population is unclear. A case-control study of 1812 subjects (965 AITD patients and 847 unrelated healthy controls) was conducted to assess AITD associations with five single nucleotide polymorphisms (SNPs), including rs4149576, rs4149577, rs4149570, rs1800693, and rs767455 in the TNFRSF1A gene locus. Genotyping was performed and evaluated using the platform of ligase detection reaction. No significant difference was observed in the allele and genotype frequencies between HT or GD patients and controls in any of the five SNPs in the TNFRSF1A gene (all p values >0.05). However, a moderate association of rs4149570 with HT was found after adjusting for age and gender [odds ratio (OR)=1.40, p=0.03]. No obvious difference was found in the haplotype distribution of any of the five SNPs in the TNFRSF1A gene between the AITD patients and controls. These data suggest that these five SNPs in the TNFRSF1A gene are not associated with AITD in the Chinese Han population, but rs4149570 shows a weak association with HT after adjusting for gender and age.

Key words

TNFRSF1A - autoimmune thyroid diseases - single nucleotide polymorphism
 

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