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Synthesis 2010(12): 2085-2091  
DOI: 10.1055/s-0029-1218734
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

A Novel Palladium-Catalyzed Cross-Coupling of Thiomethylated Alkynes with Functionalized Organozinc Reagents

Laurin Melzig, Jérémy Stemper, Paul Knochel*
Department Chemie, Ludwig-Maximilians-Universität München, Butenandtstr. 5-13, Haus F, 81377 München, Germany
Fax: +49(89)218077680; e-Mail: Paul.Knochel@cup.uni-muenchen.de;
Further Information

Publication History

Received 20 February 2010
Publication Date:
12 April 2010 (online)

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Abstract

A range of methylthio-substituted acetylenes undergo smooth palladium-catalyzed cross-coupling reactions with functionalized aryl-, heteroaryl-, and alkylzinc reagents using the Pd(OAc)2/DPE-Phos catalytic system at 25 or 50 ˚C without the need for copper salts.

Key words

alkynes - cross-coupling - organometallic reagents - palladium - zinc

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