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Synthesis 2014; 46(23): 3249-3255
DOI: 10.1055/s-0034-1378585
DOI: 10.1055/s-0034-1378585
paper
Novel and Efficient Debenzylation of N-Benzyltetrazole Derivatives with the Rosenmund Catalyst
Weitere Informationen
Publikationsverlauf
Received: 18. Juni 2014
Accepted after revision: 15. Juli 2014
Publikationsdatum:
21. August 2014 (online)
Abstract
The Rosenmund catalyst (Pd/BaSO4) was found to efficiently catalyze debenzylation of N-benzyltetrazole derivatives with ammonium formate by catalytic transfer hydrogenation under mild conditions. The protocol has been applied to functionalized substrates to provide various angiotensin II receptor blockers in excellent yields.
Supporting Information
- for this article is available online at http://www.thieme-connect.com/products/ejournals/journal/ 10.1055/s-00000084.
- Supporting Information
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