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DOI: 10.1055/s-0037-1611518
Direct Synthesis of Deuterium-Labeled O-, S-, N-Vinyl Derivatives from Calcium Carbide
We gratefully acknowledge the support from the Russian Science Foundation (Project No. 18-13-00116).Publication History
Received: 18 March 2019
Accepted after revision: 22 March 2019
Publication Date:
30 April 2019 (online)
Abstract
A novel methodology for the preparation of trideuterovinyl derivatives of high purity directly from alcohols, thiols, and NH-compounds was developed. Commercially available calcium carbide and D2O acted as a D2-acetylene source, and DMSO-d 6 was used to complete the formation of the D2C=C(D)–X fragment (X = O, S, N). Polymerization of a selected trideuterovinylated compound showed a very promising potential of these substances in the synthesis of labeled polymeric materials. Biological activity of the synthesized trideuterovinyl derivatives was evaluated and the results indicated a significant increase of cytotoxicity upon deuteration.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0037-1611518.
- Supporting Information
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