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Synthesis 2001; 2001(3): 0361-0363
DOI: 10.1055/s-2001-11425
DOI: 10.1055/s-2001-11425
short paper
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Reaction of Piperazine with Trimethylacetic Arylcarboxylic Anhydride; A Convenient Method for Preparing Monoacylated Piperazine Derivatives
Further Information
Publication History
Publication Date:
31 December 2001 (online)
A series of monosubstituted piperazine derivatives were obtained by the reaction of piperazine with trimethylacetic arylcarboxylic anhydrides in good yields, which were prepared in situ from arylcarboxylic acid with trimethylacetyl chloride in the presence of triethylamine.
piperazine - anhydride - arylcarboxylic acid - triethylamine - trimethylacetyl chloride