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Synthesis 2001; 2001(3): 0379-0381
DOI: 10.1055/s-2001-11450
short paper
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Synthesis of a Sterically Hindered Diazirine with a Satisfactory Yield: Optically Active 2-Azicamphane

Daniel Krois* , Udo H. Brinker
  • *Institut für Organische Chemie, Universität Wien, Währinger Str. 38, 1090 Wien, Austria; Tel. + 43(1)4 27 75 21 21; Fax + 43(1)4 27 75 21 40; E-mail: Udo.Brinker@univie.ac.at
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Publication Date:
31 December 2001 (online)

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The optimized synthesis of 2-azicamphane (5), a sterically hindered 3,3-dialkyldiazirine, has finally made this interesting chiral diazirine available in useful quantities. The specific reaction conditions are discussed with regard to further general applications for future syntheses of diazirines that, until now, could not be prepared.

diaziridines - chiral diazirines - carbene precursors