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Synlett 2011(7): 883-886  
DOI: 10.1055/s-0030-1259724
LETTER
© Georg Thieme Verlag Stuttgart ˙ New York

Direct Sequential C-O and C-C Formation via Double sp ² C-H Bond Activations to Construct 6H-Benzo[c]chromen-6-ones

Chang-Liang Suna, Jia Liua,b, Yang Wanga, Xiao Zhoua, Bi-Jie Lia, Zhang-Jie Shi*a,c
a Beijing National Laboratory of Molecular Sciences (BNLMS), PKU Green Chemistry Centre and Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry, Peking University, Beijing, P. R. of China
Fax: +86(10)62760890; e-Mail: zshi@pku.edu.cn;
b Department of Chemistry, China Agricultural University, Beijing, P. R. of China
c State Key Laboratory of Organometallic Chemistry, Chinese Academy of Sciences, Shanghai, P. R. of China
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Publication History

Received 4 December 2010
Publication Date:
10 March 2011 (online)

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Abstract

A new method for the direct ortho acyloxylation of sp ² C-H bond with various carboxylic acids was developed. A novel strategy to synthesize 6H-benzo[c]chromen-6-one derivatives was designed via Pd-catalyzed double activations of adjacent sp ² C-H bonds.

Key words

C-H bond activation - ortho acyloxylation - 6H-benzo[c]chromen-6-one

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