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Synlett 2011(12): 1753-1755  
DOI: 10.1055/s-0030-1260823
LETTER
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Optically Pure 1-Amino-3-aryl Indanes Exemplified by
(+)-Indatraline

Niels Grøn Nøragera,b, Linda Luise Reeh Lorentz-Petersena,c, Lars Ole Lyngsød, Jan Kehlera, Karsten Juhl*a
a Discovery Chemistry and DMPK, H., Lundbeck A/S, Otilliavej 9, 2500 Valby, Denmark
Fax: +45(364)38237; e-Mail: kaju@lundbeck.com;
b Department of Chemistry, Aarhus University, Langelandsgade 140, 8000 Aarhus C, Denmark
c Department of Chemistry, Technical University of Denmark, Bldg. 201, Kemitorvet, 2800 Kgs. Lyngby, Denmark
d Process Research, H. Lundbeck A/S, Ottiliavej 9, 2500 Valby, Denmark
Further Information

Publication History

Received 25 February 2011
Publication Date:
28 June 2011 (online)

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Abstract

A versatile procedure for the synthesis of optically pure 1-amino-3-aryl indanes is presented, exemplified by the synthesis of the triple uptake inhibitor (+)-indatraline (1).

Key words

indane - indatraline - enzymatic resolution - conjugate addition - rhodium

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