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Synthesis 2021; 53(11): 1923-1930
DOI: 10.1055/s-0040-1706008
DOI: 10.1055/s-0040-1706008
paper
Methanesulfonic Acid Catalyzed Friedel–Crafts Reaction of Electron-Rich Arenes with N-Arylmaleimides: A Highly Efficient Metal-Free Route To Access 3-Arylsuccinimides
We gratefully acknowledge the SERB (Research grant No. EMR/2017/000174) for financial support.
Abstract
Friedel–Crafts reaction is widely used for the C–C bond forming reaction to enable the direct connection of electron-rich arenes to electron-deficient olefins with high regioselectivity. Herein, a highly efficient, metal-free, and environmentally benign F–C strategy of electron-rich arenes with N-arylmaleimides has been developed for the construction of 3-arylsuccinimides in the presence of a green reagent methanesulfonic acid under mild reaction conditions. This highly facile and high-yielding protocol has compatibility with different electron-rich arenes.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0040-1706008.
- Supporting Information
Publication History
Received: 17 September 2020
Accepted after revision: 09 December 2020
Article published online:
18 January 2021
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