Journal of Pediatric Neurology 2024; 22(01): 077-084
DOI: 10.1055/s-0043-1768655
Case Report

Streptococcus constellatus-Induced Blindness in a 10-Year-Old Boy: A Case Report

Sixuan Wang*
1   Department of Infectious Disease, Key Laboratory of Major Diseases in Children, Ministry of Education, Capital Medical University, National Center for Children's Health, Beijing Children's Hospital, Beijing, China
2   Research Unit of Critical Infection in Children, Chinese Academy of Medical Sciences, Beijing, China
3   Beijing Natural Science Foundation, Beijing, China
4   Respiratory Research Project of National Clinical Research Center for Respiratory Diseases, Beijing, China
,
Zhenzhen Dou*
1   Department of Infectious Disease, Key Laboratory of Major Diseases in Children, Ministry of Education, Capital Medical University, National Center for Children's Health, Beijing Children's Hospital, Beijing, China
2   Research Unit of Critical Infection in Children, Chinese Academy of Medical Sciences, Beijing, China
3   Beijing Natural Science Foundation, Beijing, China
4   Respiratory Research Project of National Clinical Research Center for Respiratory Diseases, Beijing, China
,
Wenya Feng
1   Department of Infectious Disease, Key Laboratory of Major Diseases in Children, Ministry of Education, Capital Medical University, National Center for Children's Health, Beijing Children's Hospital, Beijing, China
2   Research Unit of Critical Infection in Children, Chinese Academy of Medical Sciences, Beijing, China
3   Beijing Natural Science Foundation, Beijing, China
4   Respiratory Research Project of National Clinical Research Center for Respiratory Diseases, Beijing, China
,
Bing Hu
1   Department of Infectious Disease, Key Laboratory of Major Diseases in Children, Ministry of Education, Capital Medical University, National Center for Children's Health, Beijing Children's Hospital, Beijing, China
2   Research Unit of Critical Infection in Children, Chinese Academy of Medical Sciences, Beijing, China
3   Beijing Natural Science Foundation, Beijing, China
4   Respiratory Research Project of National Clinical Research Center for Respiratory Diseases, Beijing, China
,
Yanhui Cui
5   Department of Ophthalmology, National Center for Children's Health, Capital Medical University, Beijing Children's Hospital, Beijing, China
,
Xiaojian Yang
6   Department of Otolaryngology, Head and Neck Surgery, National Center for Children's Health, Capital Medical University, Beijing Children's Hospital, Beijing, China
,
Li Li
5   Department of Ophthalmology, National Center for Children's Health, Capital Medical University, Beijing Children's Hospital, Beijing, China
,
Wentong Ge
6   Department of Otolaryngology, Head and Neck Surgery, National Center for Children's Health, Capital Medical University, Beijing Children's Hospital, Beijing, China
,
Gang Liu
1   Department of Infectious Disease, Key Laboratory of Major Diseases in Children, Ministry of Education, Capital Medical University, National Center for Children's Health, Beijing Children's Hospital, Beijing, China
2   Research Unit of Critical Infection in Children, Chinese Academy of Medical Sciences, Beijing, China
3   Beijing Natural Science Foundation, Beijing, China
4   Respiratory Research Project of National Clinical Research Center for Respiratory Diseases, Beijing, China
› Author Affiliations

Abstract

In this article, we report a 10-year-old boy with acute bacteremia and left eye blindness. Culture from abscess drainage was positive for Streptococcus constellatus. Infection caused by S. constellatus is rare among children, and to our knowledge, this is the first report of this pathogen causing blindness. The rapidness of progression in this case is alarming. We also summarize other cases of S. constellatus infection.

Data Availability

The original contribution presented in the study is included in the article/supplementary material. Further inquiries can be directed to the corresponding author.


Ethical Approval

The studies involving human participants were reviewed and approved by the Ethics Committee of Beijing Children's Hospital. The patients/participants provided their written informed consent to participate in the study.


Authors' Contributions

All authors listed have made a substantial, direct, and intellectual contribution to the work, and approved it for publication.


* These two authors contributed equally to this work and should be regarded as joint first authors.




Publication History

Received: 24 October 2022

Accepted: 19 March 2023

Article published online:
13 June 2023

© 2023. Thieme. All rights reserved.

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  • References

  • 1 Gharib SD, Berger DL, Choy G, Huck AE. Case Records of the Massachusetts General Hospital. Case 21-2015. A 37-year-old American man living in Vietnam, with fever and bacteremia. N Engl J Med 2015; 373 (02) 174-183
  • 2 Shires CB, Klug T, Dryden S, Ford J. Unusual cause of acute sinusitis and orbital abscess in COVID-19 positive patient: case report. Int J Surg Case Rep 2021; 79: 164-168
  • 3 Allegrini D, Reposi S, Nocerino E, Pece A. Odontogenic orbital cellulitis associated with cavernous sinus thrombosis and pulmonary embolism: a case report. J Med Case Reports 2017; 11 (01) 164
  • 4 Jones RG, Arnold B. Sudden onset proptosis secondary to cavernous sinus thrombosis from underlying mandibular dental infection. BMJ Case Rep 2009; 2009: bcr03
  • 5 Basílio AL, Cabugueira A, Borges B, Flores R, Amaro A, Magriço A. Chronic lacrimal canaliculitis - the answer to a three-year history of red eye. Arq Bras Oftalmol 2018; 81 (04) 341-343
  • 6 Bouziri A, Khaldi A, Smaoui H, Menif K, Ben Jaballah N. Fatal subdural empyema caused by Streptococcus constellatus and Actinomyces viscosus in a child--case report. J Microbiol Immunol Infect 2011; 44 (05) 394-396
  • 7 Simpson R, Myer Iv C, Siracusa C. Acute respiratory distress syndrome immediately following the removal of an aspirated foreign body. Respir Med Case Rep 2019; 29: 100978
  • 8 Hu H, Dong F, Ning X, Xie Y, Guo X, Guo L, Liu G. Streptococcus anginosus group infection in 119 children: A case series report. Chin J Evid Based Pediatr 2020; 15 (02) 125-129
  • 9 Vloka CN, Kim DH, Ng JD. Microbiology of orbital cellulitis with subperiosteal abscess in children: prevalence and characteristics of Streptococcus anginosus group infection. Orbit 2022; 41 (02) 204-210
  • 10 Branson SV, McClintic E, Yeatts RP. Septic cavernous sinus thrombosis associated with orbital cellulitis: a report of 6 cases and review of literature. Ophthal Plast Reconstr Surg 2019; 35 (03) 272-280
  • 11 Hadid OH, Shah SP, Sherafat H, Graham EM, Stanford MR. Streptococcus anginosus-associated endogenous endophthalmitis mimicking fungal endophthalmitis. J Clin Microbiol 2005; 43 (08) 4275-4276
  • 12 Itoh M, Ikewaki J, Kimoto K, Itoh Y, Shinoda K, Nakatsuka K. Two cases of endogenous endophthalmitis caused by gram-positive bacteria with good visual outcome. Case Rep Ophthalmol 2010; 1 (02) 56-62
  • 13 Halawa A, Kim J, Trobe JD. Retinal, optic nerve, and cerebral infarction in odontogenic Lemierre syndrome. J Neuroophthalmol 2022; 42 (01) e443-e445
  • 14 Chou YP, Yeh PH, Tsai YJ, Yen CH, Hsiao CH. Infectious keratitis secondary to canaliculitis with concretions: a case report. Medicine (Baltimore) 2019; 98 (40) e17444
  • 15 Sakaida H, Kobayashi M, Ito A, Takeuchi K. Cavernous sinus thrombosis: linking a swollen red eye and headache. Lancet 2014; 384 (9946): 928