Synlett 2013; 24(20): 2735-2739
DOI: 10.1055/s-0033-1338985
letter
© Georg Thieme Verlag Stuttgart · New York

Copper-Mediated Sequential C–N and N–N Bond Formation: Facile Synthesis of Symmetrical 1,2,4-Triazoles

Zhonglian Li
Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, Henan 453007, P. R. of China   Fax: +86(373)3325250   Email: zhangzg@htu.edu.cn   Email: zgs6668@yahoo.com
,
Zhiguo Zhang*
Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, Henan 453007, P. R. of China   Fax: +86(373)3325250   Email: zhangzg@htu.edu.cn   Email: zgs6668@yahoo.com
,
Wei Zhang
Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, Henan 453007, P. R. of China   Fax: +86(373)3325250   Email: zhangzg@htu.edu.cn   Email: zgs6668@yahoo.com
,
Qingfeng Liu
Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, Henan 453007, P. R. of China   Fax: +86(373)3325250   Email: zhangzg@htu.edu.cn   Email: zgs6668@yahoo.com
,
Tongxin Liu
Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, Henan 453007, P. R. of China   Fax: +86(373)3325250   Email: zhangzg@htu.edu.cn   Email: zgs6668@yahoo.com
,
Guisheng Zhang*
Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, Henan 453007, P. R. of China   Fax: +86(373)3325250   Email: zhangzg@htu.edu.cn   Email: zgs6668@yahoo.com
› Author Affiliations
Further Information

Publication History

Received: 26 June 2013

Accepted after revision: 09 September 2013

Publication Date:
28 October 2013 (online)


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Abstract

Via a one-pot process, catalyzed by Cu(OAc)2, a series of 3,5-disubstituted 4H-1,2,4-triazoles was conveniently and efficiently synthesized by using low-toxicity, stable, readily available, inexpensive amidine hydrochloride.

Supporting Information