The over-the-scope clip (OTSC) system was developed for the closure of gastrointestinal
defects but can also be used for endoscopic resection. This report describes the efficacy
and safety of endoscopic full-thickness resection (eFTR) using the OTSC system. In
this retrospective, observational, open-label case study, a total of 17 patients underwent
eFTR using a dual clip and cap technique. The indications were: carcinoids, incompletely
resected colon cancers involving the mucosa or submucosa, recurrent fibrosed adenoma
of the colon, and submucosal lesions. The technical success was 94 % (16 /17). The
complete resection (R0) rate was 100 %. There were no complications. In summary, the
described minimally invasive method to perform eFTR of complex gastrointestinal lesions
appears to be effective and safe.