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AJP Rep 2015; 05(02): e168-e171
DOI: 10.1055/s-0035-1555128
Case Report
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Bile Acid Determination after Standardized Glucose Load in Pregnant Women

April Adams
1   Department of Obstetrics and Gynecology, University of Minnesota, Minneapolis, Minnesota
,
Katherine Jacobs
1   Department of Obstetrics and Gynecology, University of Minnesota, Minneapolis, Minnesota
,
Rachel Isaksson Vogel
2   Biostatistics and Bioinformatics Core, Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota
,
Virginia Lupo
3   Department of Obstetrics and Gynecology, Hennepin County Medical Center, Minneapolis, Minnesota
› Author Affiliations
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Publication History

02 February 2015

14 May 2015

Publication Date:
19 June 2015 (online)

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Abstract

Objective Intrahepatic cholestasis of pregnancy (ICP) is a rare liver disorder, usually manifesting in the third trimester and associated with increased perinatal morbidity and mortality. The hallmark laboratory abnormality in ICP is elevated fasting serum bile acids; however, there are limited data on whether a nonfasting state affects a pregnant woman's total bile acids. This study assesses fasting and nonfasting bile acid levels in 10 healthy pregnant women after a standardized glucose load to provide insight into the effects of a glucose load on bile acid profiles.

Study Design Pilot prospective cohort analysis of serum bile acids in pregnant women. A total of 10 healthy pregnant women from 28 to 32 weeks' gestation were recruited for the study before undergoing a glucose tolerance test. Total serum bile acids were collected for each subject in the overnight fasting state, and 1 and 3 hours after the 100-g glucose load.

Results There was a statistically significant difference between fasting versus 3-hour values. There was no statistically significant difference between fasting versus 1-hour and 1-hour versus 3-hour values.

Conclusion There is a difference between fasting and nonfasting total serum bile acids after a 100-g glucose load in healthy pregnant women.

Keywords

bile acids - cholestasis - pregnancy - liver disease

Note

This article was presented as a poster at the 80th Annual Meeting for the Central Association of Obstetricians and Gynecologists, October 16 to 18, 2013.