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Synlett 1998; 1998(6): 661-663
DOI: 10.1055/s-1998-1721
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Synthesis of Imidazo[1,2-a] annulated Pyridines, Pyrazines and Pyrimidines by a Novel Three-Component Condensation

Katrin Groebke* , Lutz Weber, Fridolin Mehlin
  • *Pharma Division, Preclinical Research, F. Hoffmann-La Roche AG, 4070 Basel, Switzerland
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Publikationsdatum:
31. Dezember 2000 (online)

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A novel three-component, one-pot condensation yielding 3-amino-substituted imidazo[1,2-a]pyridines, imidazo[1,2-a]pyrazines and imidazo[1,2-a]pyrimidines from aldehydes, isonitriles and 2-amino-pyridine, 2-amino-pyrazine or 2-amino-pyrimidine is described.

combinatorial chemistry - multicomponent condensation - Ugi reaction - heterobicyclic compounds - imidazopyridines - imidazopyrazines - imidazopyrimidines