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Synlett 2001; 2001(12): 1925-1926
DOI: 10.1055/s-2001-18767
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A Convenient Protecting Group for Aldehydes

Long Guo Quan* , Jin Kun Cha
  • *Department of Chemistry, University of Alabama, Tuscaloosa, AL 35487, USA; Fax: + 1(205)3489104; E-mail: jcha@bama.ua.edu
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Publication History

Publication Date:
04 December 2001 (online)

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Aldehydes were cleanly and chemoselectively protected by treatment with tert-butylchlorodimethylsilane and imidazole. The resulting O-tert-butyldimethylsilylimidazolyl aminals were deblocked under mild conditions by employing 9 : 1 CH3CN-49% HF.

protecting group - aldehydes - tert-butylchlorodimethylsilane - imidazole - 49% HF