The Influence of Acidity on Direct Aldol Reactions Catalyzed by Pyrrolidine/Acid Bifunctional Organocatalyst

Changyun Ji; Yungui Peng; Chengzhi Huang; Ning Wang; Yaozhong Jiang

doi:10.1055/s-2005-864823

LETTER

The Influence of Acidity on Direct Aldol Reactions Catalyzed by Pyrrolidine/Acid Bifunctional Organocatalyst

Changyun Ji^a, Yungui Peng*^a, Chengzhi Huang^a, Ning Wang^a, Yaozhong Jiang^b
^a The School of Chemistry and Chemical Engineering, Southwest Normal University, Beibei, Chongqing, 400715, P. R. China
^b Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu, 610041, P. R. China
Fax: +86(23)68254000; e-Mail: pengyungui@hotmail.com;

Abstract

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Abstract

The match of the acidity and basicity is very important to obtain good reactivity and high yield in the pyrrolidine/acid bifunctional organocatalyst system. The combination of pyrrolidine/p-nitrophenol was a high efficiency catalyst, which has been employed in the direct aldol reaction of aldehydes and ketones with yields up to 99%.

Key words

acidity - aldol reaction - pyrrolidine - p-nitrophenol - bifunctional catalysis

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References

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