Abstract
A simple liquid phase synthetic method for the preparation of 4-methyl coumarin on
modified poly(ethylene glycol)s by using the von Pechmann reaction is described.
Key words
von Pechmann condensation - multicomponent reaction - liquid phase synthesis - heterocycles
- coumarins
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Analytical details for compounds 9 and 15. 9. 1H NMR (300 MHz, CDCl3): δ = 2.40 (s, 3 H), 3.36 (s, 3 H), 6.20 (s, 1 H), 6.80 (s, 4
J = 2.43 Hz, 1 H), 6.90 (d, 3
J = 8.50 Hz, 4
J = 2.43 Hz, 1 H), 7.60 (s, 3
J = 8.50 Hz, 1 H). 15.
1H NMR (300 MHz, CDCl3): δ = 1.81 (m, 2 H), 2.40 (s, 3 H), 2.70 (t, 2 H), 3.36 (s, 3 H), 3.92 (t, 2 H),
6.18 (d, 3
J = 8.50 Hz, 2 H), 6.30 (s, 1 H), 6.81 (d, 3
J = 8.41, 1 H), 6.88 (s, 1 H), 6.98 (d, 3
J = 8.50, 2 H), 7.50 (d, 3
J = 8.41, 1 H).
