Direct Oxidative Conversion of Primary Alcohols to Nitriles Using Molecular Iodine in Ammonia Water

Naoshi Mori; Hideo Togo

doi:10.1055/s-2005-868511

LETTER

Direct Oxidative Conversion of Primary Alcohols to Nitriles Using Molecular Iodine in Ammonia Water

Naoshi Mori^a, Hideo Togo*^a,b
^a Graduate School of Science and Technology, Chiba University, Yayoi-cho 1-33. Inage-ku, Chiba 263-8522, Japan
^b Department of Chemistry, Faculty of Science, Chiba University, Yayoi-cho 1-33. Inage-ku, Chiba 263-8522, Japan
Fax: +81(43)2902874; e-Mail: togo@faculty.chiba-u.jp;

Abstract

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Abstract

A simple, effective, high-yield procedure for the direct oxidative conversion of alcohols to nitriles, was successfully carried out with molecular iodine in ammonia water.

Key words

molecular iodine - oxidation - alcohol - nitrile - ammonia water

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References

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CAUTION: It is known that iodine reacts with ammonia water under certain conditions to give a black powder of nitrogen triiodide monoamine (NI₃·NH₃). The dry powder explodes readily by mechanical shock, heat or irradiation. Although we did not have any incidents in this study, one should be careful.

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