Summary
Despite current guidelines, venous thromboembolism (VTE) prophylaxis is underused.
Computerized programs to encourage physicians to apply thromboprophylaxis have been
shown to be effective in selected populations. Our aim was to analyze the impact of
the implementation of a computer- alert system for VTE risk in all hospitalized patients
of a teaching hospital. A computer program linked to the clinical record database
was developed to assess all hospitalized patients’VTE risk daily. The physician responsible
for patients at high risk was alerted, but remained free to order or withhold prophylaxis.
Over 19,000 hospitalized, medical and surgical, adult patients between January to
June 2005 (pre-intervention phase), January to June 2006 and January to June 2007
(postintervention phase), were included. During the first semesters of 2006 and 2007,
an electronic alert was sent to 32.8% and 32.2% of all hospitalized patients, respectively.
Appropriate prophylaxis among alerted patients was ordered in 89.7% (2006) and 88.5%
(2007) of surgical patients, and in 49.2% (2006) and 64.4% (2007) of medical patients.
A sustained reduction of VTE during hospitalization was achieved, Odds ratio (OR):
0.53, 95% confidence interval (CI) (0.25–1.10) and OR: 0.51, 95%CI (0.24–1.05) during
the first semesters of 2006 and 2007 respectively, the impact being significant (p<0.05)
among medical patients in 2007, OR: 0.36, 95%CI (0.12–0.98). The implementation of
a computer- alert program helps physicians to assess each patient’s thrombotic risk,
leading to a better use of thromboprophylaxis, and a reduction in the incidence of
VTE among hospitalized patients. For the first time, an intervention aimed to improveVTE
prophylaxis shows maintained effectiveness over time.
Keywords
Electronic alert - hospitalized patients - prophylaxis - venous thromboembolism