Thrombosis and Haemostasis

Issue 10 · 2008

Editorial Focus
517
Malmström, Rickard E.; Hjemdahl, Paul:
Dyspnea and antiplatelet drugs: Little cause for concern with clopidogrel

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519
Horowitz, John D.; Chirkov, Yuliy Y.:
Identifying clopidogrel resistance during chronic therapy: The case for a biochemical approach

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521
Biondi-Zoccai, Giuseppe; Lotrionte, Marzia; Sheiban, Imad:
Overcoming “resistance” to aspirin and clopidogrel with tirofiban: fact or fiction?

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523
Warkentin, Theodore E.:
Confirmatory procedure and other maneuvers to assess pathogenicity of platelet factor 4 (PF4)-dependent antibodies – distinguishing "signal" from "noise"

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525
Marco, Pascual; Lopez-Abadia, Emma; Lucas, Javier:
More on thromboprophylaxis: Electronic alerts in hospitalized patients at risk of venous thromboembolism

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Theme Issue Editorial
527
Benzakour, Omar:
Vitamin K-dependent proteins: Functions in blood coagulation and beyond

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Theme Issue Article
530
Shearer, Martin J.; Newman, Paul:
Metabolism and cell biology of vitamin K

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548
Vasse, Marc:
Protein Z, a protein seeking a pathology

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557
Hedner, Ulla:
Factor VIIa and its potential therapeutic use in bleeding-associated pathologies

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563
Monahan, Paul E.:
Factor IX: Insights from knock-out and genetically engineered mice

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576
Sokolova, Elena; Reiser, Georg:
Prothrombin/thrombin and the thrombin receptors PAR-1 and PAR-4 in the brain: Localization, expression and participation in neurodegenerative diseases

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582
Toltl, Lisa J.; Swystun, Laura L.; Pepler, Laura; Liaw, Patricia C.:
Protective effects of activated protein C in sepsis

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593
Schurgers, Leon J.; Cranenburg, Ellen C. M.; Vermeer, Cees:
Matrix Gla-protein: The calcification inhibitor in need of vitamin K

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604
Fernández-Fernández, Laura; Bellido-Martín, Lola; García de Frutos, Pablo:
Growth arrest-specific gene 6 (GAS6)

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Clinical Focus
611
Goto, Shinya:
Cardiovascular risk factors in patients at high risk of atherothrombosis: What can be learned from registries?

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Blood Coagulation, Fibrinolysis and Cellular Haemostasis
614
Arnold, Marie-Luise; Lichy, Christoph; Werner, Inge; Radbruch, Alexander; Wagner, Simone; Grond-Ginsbach, Caspar:
Single nucleotide polymorphisms in the VKORC1 gene and the risk of stroke in the Southern German population

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Platelets and Blood Cells
618
Schäfer, Andreas; Weinberger, Sarah; Flierl, Ulrike; Eigenthaler, Martin; Störk, Stefan; Walter, Ulrich; Ertl, Georg; Bauersachs, Johann:
ADP-induced platelet aggregation frequently fails to detect impaired clopidogrel-responsiveness in patients with coronary artery disease compared to a P2Y₁₂-specific assay

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626
Braun, Oscar Ö.; Johnell, Matilda; arenhorst, Christoph; James, Stefan; Brandt, John T.; Jakubowski, Joseph A.; Winters, Kenneth J.; Wallentin, Lars; Erlinge, David; Siegbahn, Agneta:
Greater reduction of platelet activation markers and platelet-monocyte aggregates by prasugrel compared to clopidogrel in stable coronary artery disease

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634
Larson, Mark K.; Ashmore, Joseph H.; Harris, Kristina A.; Vogelaar, Jessica L.; Pottala, James V.; Sprehe, Michael; Harris, William S.:
Effects of omega-3 acid ethyl esters and aspirin, alone and in combination, on platelet function in healthy subjects

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Endothelium and Vascular Development
642
Strijbos, Michiel H.; Rao, Chandra; Schmitz, Paul I. M.; Kraan, Jaco; Lamers, Cor H.; Sleijfer, Stefan; Terstappen, Leon W. M. M.; Gratama, Jan W.:
Correlation between circulating endothelial cell counts and plasma thrombomodulin levels as markers for endothelial damage

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Cardiovascular Biology and Cell Signalling
648
Ivandic, Boris T.; Kurz, Kerstin; Keck, Frieder; Staritz, Peter; Lehrke, Stephanie; Katus, Hugo A.; Giannitsis, Evangelos:
Tirofiban optimizes platelet inhibition for immediate percutaneous coronary intervention in high-risk acute coronary syndromes

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Cellular Proteolysis and Oncology
655
Åberg, Mikael; Johnell, Matilda; Wickström, Malin; Widunder, Anna; Siegbahn, Agneta:
Simvastatin reduces the production of prothrombotic prostasomes in human prostate cancer cells

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663
Toth, Bettina; Liebhardt, Susanne; Steinig, Kerstin; Ditsch, Nina; Rank, Andreas; Bauerfeind, Ingo; Spannagl, Michael; Friese, Klaus; Reininger, Armin J.:
Platelet-derived microparticles and coagulation activation in breast cancer patients

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Animal Models
670
Fontayne, Alexandre; Meiring, Muriel; Lamprecht, Seb; Roodt, Jan; Demarsin, Eddy; Barbeaux, Philippe; Deckmyn, Hans:
The humanized anti-glycoprotein Ib monoclonal antibody h6B4-Fab is a potent and safe antithrombotic in a high shear arterial thrombosis model in baboons

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New Technologies, Diagnostic Tools and Drugs
678
Whitlatch, Nicole L.; Perry, Stephanie L.; Ortel, Thomas L.:
Anti-heparin/platelet factor 4 antibody optical density values and the confirmatory procedure in the diagnosis of heparin-induced thrombocytopenia

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685
Cadiou, Gwenaëlle; Varin, Rémi; Levesque, Hervé; Grassi, Vanessa; Benichou, Jacques; Tiret, Isabelle; Dieu, Bernard; Lecam-Duchez, Véronique; Borg, Jeanne-Yvonne; Muller, Jean-Michel; Benhamou, Ygal; Marie, Isabelle:
Risk factors of vitamin K antagonist overcoagulation

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693
Maegdefessel, Lars; Buerke, Michael; Schubert, Sebastian; Reindl, Iris; Michel, Thomas; Hauroeder, Baerbel; Carter, Justin M.; Peetz, Dirk; Werdan, Karl; Schlitt, Axel:
Comparison of bivalirudin, enoxaparin, and unfractionated heparin in preventing cardiac catheter thrombosis

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699
Lecumberri, Ramón; Marqués, Margarita; Díaz-Navarlaz, María Teresa; Panizo, Elena; Toledo, Jon; García-Mouriz, Alberto; Páramo, José A.:
Maintained effectiveness of an electronic alert system to prevent venous thromboembolism among hospitalized patients

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Case Report
705
Weigert, Oliver; Wittmann, Georg; Gruetzner, Stefanie; Cnossen, Jitske; Becker, Marie-Christine; Dreyling, Martin; Ostermann, Helmut:
Successful salvage treatment of chronic refractory immune thrombocytopenia using a simplified method to generate vincristine-loaded platelets

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708
Davis, Ryan L.; Baker, Bartrum; Brennan, Stephen O.:
Fibrinogen Foxton: A novel BβA277V mutation causing low normal plasma fibrinogen concentration

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711
Marschang, Peter; Niederwanger, Andreas; Gasser, Rudolf W.; Daniaux, Martin; Sturm, Wolfgang:
Symptomatic upper extremity deep vein thrombosis as a complication of ambulatory blood pressure monitoring

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Letters to the Editor
713
Aleil, Boris; Kessler, Laurence; Meyer, Nicolas; Wiesel, Marie-Louise; Simeoni, Julia; Cazenave, Jean-Pierre; Pinget, Michel; Gachet, Christian; Lanza, François:
Plasma levels of soluble platelet glycoprotein V are linked to fasting blood glucose in patients with type 2 diabetes

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716
Lester, William; Guilliatt, Andrea; Grundy, Pamela; Enayat, Said; Millar, Carolyn; Hill, Frank; Cumming, Tony; Collins, Peter:
Is VWF R924Q a benign polymorphism, a marker of a null allele or a factor VIII-binding defect? The debate continues with results from the UKHCDO VWD study

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718
Pengo, Vittorio; Palareti, Gualtiero; Cosmi, Benilde; Legnani, Cristina; Tosetto, Alberto; Alatri, Adriano; Marzot, Filippo; Pegoraro, Cinzia; Cucchini, Umberto; Iliceto, Sabino; for the PROLONG Investigators (on behalf of FCSA, Italian Federation of Anticoagulation Clinics):
D-dimer testing and recurrent venous thromboembolism after unprovoked pulmonary embolism: A post-hoc analysis of the prolong extension study

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721
Hurtado, Begoña; Abasolo, Nerea; Domènech-Santasusana, Pere; Fuentes-Prior, Pablo; de Frutos, Pablo García; Sala, Núria:
Confirmation of inherited protein S deficiency by PROS1 mutational screening: Identification of three novel PROS1 mutations and haplotype analysis of p.Q279X recurrence

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725
Breugelmans, Jaimie; Vertessen, Francine; Mertens, Gerhard; Gadisseur, Alain; Van der Planken, Marc:
Multiplate whole blood impedance aggregometry: A recent experience

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Thrombosis and Haemostasis

Dyspnea and antiplatelet drugs: Little cause for concern with clopidogrel

Identifying clopidogrel resistance during chronic therapy: The case for a biochemical approach

Overcoming “resistance” to aspirin and clopidogrel with tirofiban: fact or fiction?

Confirmatory procedure and other maneuvers to assess pathogenicity of platelet factor 4 (PF4)-dependent antibodies – distinguishing "signal" from "noise"

More on thromboprophylaxis: Electronic alerts in hospitalized patients at risk of venous thromboembolism

Vitamin K-dependent proteins: Functions in blood coagulation and beyond

Metabolism and cell biology of vitamin K

Protein Z, a protein seeking a pathology

Factor VIIa and its potential therapeutic use in bleeding-associated pathologies

Factor IX: Insights from knock-out and genetically engineered mice

Prothrombin/thrombin and the thrombin receptors PAR-1 and PAR-4 in the brain: Localization, expression and participation in neurodegenerative diseases

Protective effects of activated protein C in sepsis

Matrix Gla-protein: The calcification inhibitor in need of vitamin K

Growth arrest-specific gene 6 (GAS6)

Cardiovascular risk factors in patients at high risk of atherothrombosis: What can be learned from registries?

Single nucleotide polymorphisms in the VKORC1 gene and the risk of stroke in the Southern German population

ADP-induced platelet aggregation frequently fails to detect impaired clopidogrel-responsiveness in patients with coronary artery disease compared to a P2Y₁₂-specific assay

Greater reduction of platelet activation markers and platelet-monocyte aggregates by prasugrel compared to clopidogrel in stable coronary artery disease

Effects of omega-3 acid ethyl esters and aspirin, alone and in combination, on platelet function in healthy subjects

Correlation between circulating endothelial cell counts and plasma thrombomodulin levels as markers for endothelial damage

Tirofiban optimizes platelet inhibition for immediate percutaneous coronary intervention in high-risk acute coronary syndromes

Simvastatin reduces the production of prothrombotic prostasomes in human prostate cancer cells

Platelet-derived microparticles and coagulation activation in breast cancer patients

The humanized anti-glycoprotein Ib monoclonal antibody h6B4-Fab is a potent and safe antithrombotic in a high shear arterial thrombosis model in baboons

Anti-heparin/platelet factor 4 antibody optical density values and the confirmatory procedure in the diagnosis of heparin-induced thrombocytopenia

Risk factors of vitamin K antagonist overcoagulation

Comparison of bivalirudin, enoxaparin, and unfractionated heparin in preventing cardiac catheter thrombosis

Maintained effectiveness of an electronic alert system to prevent venous thromboembolism among hospitalized patients

Successful salvage treatment of chronic refractory immune thrombocytopenia using a simplified method to generate vincristine-loaded platelets

Fibrinogen Foxton: A novel BβA277V mutation causing low normal plasma fibrinogen concentration

Symptomatic upper extremity deep vein thrombosis as a complication of ambulatory blood pressure monitoring

Plasma levels of soluble platelet glycoprotein V are linked to fasting blood glucose in patients with type 2 diabetes

Is VWF R924Q a benign polymorphism, a marker of a null allele or a factor VIII-binding defect? The debate continues with results from the UKHCDO VWD study

D-dimer testing and recurrent venous thromboembolism after unprovoked pulmonary embolism: A post-hoc analysis of the prolong extension study

Confirmation of inherited protein S deficiency by PROS1 mutational screening: Identification of three novel PROS1 mutations and haplotype analysis of p.Q279X recurrence

Multiplate whole blood impedance aggregometry: A recent experience