Cellular immunity, low-density lipoprotein and atherosclerosis: Break of tolerance in the artery wall

Daniel F. J. Ketelhuth; Göran K. Hansson

doi:10.1160/TH11-05-0321

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 2011; 106(05): 779-786
DOI: 10.1160/TH11-05-0321

Theme Issue Article

Schattauer GmbH

Cellular immunity, low-density lipoprotein and atherosclerosis: Break of tolerance in the artery wall

Authors

Daniel F. J. Ketelhuth

¹Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
Göran K. Hansson

Abstract

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Summary

Atherosclerosis is a chronic inflammatory disease. Atherosclerotic plaques contain abundant immune cells that can dictate and effect inflammatory responses. Among them, T cells are present during all stages of the disease suggesting that they are essential in the initiation as well as the progression of plaque. Experimental as well as clinical research has demonstrated different T cell subsets, i.e. CD4⁺ Th1, Th2, Th17, and Treg as well as CD8⁺ and NKT cells in the plaque. Moreover, candidate antigens inducing T cell responses have been identified. Knowledge about the pathological role of these cells in atherogenesis may lead to development of new therapies. This review provides an overview of the research field of cellular immunity in atherosclerosis. It emphasises the events and findings involving antigen specific T cells, in particular low-density lipoprotein-specific T cells.

Keywords

Atherosclerosis - immunity - inflammation - lipoproteins

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Referenzen

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