Endoscopy 2018; 50(10): 1017-1021
DOI: 10.1055/a-0622-8019
Innovations and brief communications
© Georg Thieme Verlag KG Stuttgart · New York

Endoscopic mucosal autograft for treating esophageal caustic strictures: preliminary human experience

Kexin He*
1  Digestive Endoscopy Department, The First Affiliated Hospital with Nanjing Medical University, China
,
Lili Zhao*
1  Digestive Endoscopy Department, The First Affiliated Hospital with Nanjing Medical University, China
,
Shoushan Bu
2  Department of Stomatology, The First Affiliated Hospital with Nanjing Medical University, China
,
Li Liu
1  Digestive Endoscopy Department, The First Affiliated Hospital with Nanjing Medical University, China
,
Xiang Wang
1  Digestive Endoscopy Department, The First Affiliated Hospital with Nanjing Medical University, China
,
Min Wang
1  Digestive Endoscopy Department, The First Affiliated Hospital with Nanjing Medical University, China
,
Zhining Fan
1  Digestive Endoscopy Department, The First Affiliated Hospital with Nanjing Medical University, China
› Author Affiliations
Further Information

Publication History

submitted 14 September 2017

accepted after revision 21 March 2018

Publication Date:
11 June 2018 (eFirst)

Abstract

Background Esophageal caustic stricture is a stubborn disease and postoperative restenosis limits the clinical efficacy of endoscopic dilation. Autologous mucosal grafts have been successfully applied in the treatment of urethral stricture and in the prevention of stricture after extensive mucosal resection. We aimed to use mucosal autografting performed endoscopically to treat refractory esophageal stricture.

Methods Three patients with intractable corrosive esophageal stricture were treated endoscopically by combining dilation with autologous mucosal transplantation.

Results All procedures were successful with no severe complications. Mucosal regeneration was shown at the transplanted segments. One patient was able to maintain a normal diet with complete remission after 1 year of follow-up. Intraluminal stenosis and dysphagia were significantly improved in another two patients.

Conclusions Mucosal autografting can achieve esophageal re-epithelialization, inhibit undesired fibrosis, prevent restenosis, and promote functional regeneration.

* These authors contributed equally to this work.


Supplementary material Appendix e1, Table e1, Figs. e2, e4, e5, e6, e7, e8