Drug Res (Stuttg) 2018; 68(11): 653-660
DOI: 10.1055/a-0630-4988
Original Article
© Georg Thieme Verlag KG Stuttgart · New York

Synthesis of Novel tricyclic pyrazolo(1,4)oxathiinopyrazines and Evaluation of Their Competency Towards the Inhibition of Lactate Dehydrogenase Activity-Inhibition of LDH Activity

Prasun Mukherjee
1   Department of Chemistry, University of Calcutta, Kolkata, India
,
Asish R. Das
1   Department of Chemistry, University of Calcutta, Kolkata, India
,
Raghwendra Mishra
2   Department of Physiology, University of Calcutta, Kolkata, India
,
Shovonlal Bhowmick
3   Department of Chemical Technology, University of Calcutta, Kolkata, India
,
Achintya Saha
3   Department of Chemical Technology, University of Calcutta, Kolkata, India
› Author Affiliations
Further Information

Publication History

received 09 March 2018

accepted 12 May 2018

Publication Date:
12 June 2018 (online)

Abstract

We have evaluated the LDH inhibitory property of novel pyrazolo[4′,3′:5,6][1,4]oxathiino[2,3-b]pyrazine derivatives which have been synthesized from easily available starting materials through a one-pot protocol that offers the use of elemental sulfur as the sulfur source. These newly synthesized compounds may aid to drug development for neoplastic and non-neoplastic diseases characterized by increased glucose metabolism. Additionally, they may act as suitable starting materials which can be further structurally modified for the development of new LDH inhibitors with higher efficacy and specificity.

Supporting Information

 
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