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TumorDiagnostik & Therapie 2018; 39(07): 468-474
DOI: 10.1055/a-0635-5628
Thieme Onkologie aktuell
© Georg Thieme Verlag KG Stuttgart · New York

Vitamine und Spurenelemente in der Onkologie

Vitamins and Minerals in OncologyRezensent(en):
Julian Walter Holch
,
Marlies Michl
,
Volker Heinemann
,
Nicole Erickson
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Publikationsverlauf

Publikationsdatum:
31. August 2018 (online)

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Zusammenfassung

Vitamine und Spurenelemente werden häufig von Patienten eingenommen, um Tumorerkrankungen vorzubeugen oder deren Fortschreiten zu verhindern. Dies geschieht oft auch ohne Wissen des behandelnden Arztes. Der vorliegende Artikel beleuchtet die aktuelle Evidenzlage zu den meist untersuchten Mikronährstoffen und leitet hieraus konkrete Handlungsempfehlungen ab.

Abstract

The use of vitamins and minerals to prevent cancer as well as their supportive use in oncological patients is widespread and often occurs without the knowledge of the treating physician. Beyond general recommendations with regard to a balanced and healthy diet, no evidence exists supporting the use of vitamins and minerals in the prevention of cancer. Furthermore, the diet of oncological patients should contain vitamins and minerals of the same quantity as for healthy individuals. In particular, there is currently no rationale for a high-dosage administration of antioxidants.

Schlüsselwörter

Vitamine - Spurenelemente - Mikronährstoffe - Onkologie - Prävention

Key words

vitamins - minerals - oncology - prevention
 

  • Literatur

  • 1 Molassiotis A. Fernadez-Ortega P. Pud D. et al. Use of complementary and alternative medicine in cancer patients: a European survey. Ann Oncol 2005; 16: 655-663
    CrossrefPubMedGoogle Scholar
  • 2 Velicer CM. Ulrich CM. Vitamin and mineral supplement use among US adults after cancer diagnosis: a systematic review. J Clin Oncol 2008; 26: 665-673
    CrossrefPubMedGoogle Scholar
  • 3 Gröber U. Mücke R. Adamietz IA. Komplementärer Einsatz von Antioxidanzien und Mikronährstoffen in der Onkologie. Onkologe 2013; 18: 136
    PubMedGoogle Scholar
  • 4 Valko M. Rhodes CJ. Moncol J. Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chem Biol Interact 2006; 160: 1-40
    CrossrefPubMedGoogle Scholar
  • 5 Willcox JK. Ash SL. Catignani GL. Antioxidants and prevention of chronic disease. Crit Rev Food Sci Nutr 2004; 44: 275-295
    CrossrefPubMedGoogle Scholar
  • 6 Bjelakovic G. Nikolova D. Gluud LL. et al. Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases. Cochrane Database Syst Rev 2012; DOI: CD007176.
    CrossrefPubMedGoogle Scholar
  • 7 Vinceti M. Dennert G. Crespi CM. et al. Selenium for preventing cancer. Cochrane Database Syst Rev 2014; DOI: CD005195.
    CrossrefPubMedGoogle Scholar
  • 8 The Alpha-Tocopherol, Beta Carotene Cancer Prevention Study Group. The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. N Engl J Med 1994; 330: 1029-1035
    CrossrefPubMedGoogle Scholar
  • 9 Goodman GE. Thornquist MD. Balmes J. et al. The Beta-Carotene and Retinol Efficacy Trial: incidence of lung cancer and cardiovascular disease mortality during 6-year follow-up after stopping beta-carotene and retinol supplements. J Natl Cancer Inst 2004; 96: 1743-1750
    CrossrefPubMedGoogle Scholar
  • 10 Lippman SM. Klein EA. Goodman PJ. et al. Effect of selenium and vitamin E on risk of prostate cancer and other cancers: the Selenium and Vitamin E Cancer Prevention Trial (SELECT). JAMA 2009; 301: 39-51
    CrossrefPubMedGoogle Scholar
  • 11 Klein EA. Thompson IM. Tangen CM. et al. Vitamin E and the risk of prostate cancer: the Selenium and Vitamin E Cancer Prevention Trial (SELECT). JAMA 2011; 306: 1549-1556
    CrossrefPubMedGoogle Scholar
  • 12 Miller ER. Pastor-Barriuso R. Dalal D. et al. Meta-analysis: high-dosage vitamin E supplementation may increase all-cause mortality. Ann Intern Med 2005; 142: 37-46
    CrossrefPubMedGoogle Scholar
  • 13 Ebbing M. Bonaa KH. Nygard O. et al. Cancer incidence and mortality after treatment with folic acid and vitamin B12. JAMA 2009; 302: 2119-2126
    CrossrefPubMedGoogle Scholar
  • 14 Freedman DM. Looker AC. Abnet CC. et al. Serum 25-hydroxyvitamin D and cancer mortality in the NHANES III study (1988–2006). Cancer Res 2010; 70: 8587-8597
    CrossrefPubMedGoogle Scholar
  • 15 Bjelakovic G. Gluud LL. Nikolova D. et al. Vitamin D supplementation for prevention of cancer in adults. Cochrane Database Syst Rev 2014; DOI: CD007469.
    CrossrefPubMedGoogle Scholar
  • 16 Neuhouser ML. Wassertheil-Smoller S. Thomson C. et al. Multivitamin use and risk of cancer and cardiovascular disease in the Women's Health Initiative cohorts. Arch Intern Med 2009; 169: 294-304
    CrossrefPubMedGoogle Scholar
  • 17 Park SY. Murphy SP. Wilkens LR. et al. Multivitamin use and the risk of mortality and cancer incidence: the multiethnic cohort study. Am J Epidemiol 2011; 173: 906-914
    CrossrefPubMedGoogle Scholar
  • 18 Gaziano JM. Glynn RJ. Christen WG. et al. Vitamins E and C in the prevention of prostate and total cancer in men: the Physicians' Health Study II randomized controlled trial. JAMA 2009; 301: 52-62
    CrossrefPubMedGoogle Scholar
  • 19 Hercberg S. Galan P. Preziosi P. et al. The SU.VI.MAX Study: a randomized, placebo-controlled trial of the health effects of antioxidant vitamins and minerals. Arch Intern Med 2004; 164: 2335-2342
    CrossrefPubMedGoogle Scholar
  • 20 Fortmann SP. Burda BU. Senger CA. et al. Vitamin and mineral supplements in the primary prevention of cardiovascular disease and cancer: An updated systematic evidence review for the U. S. Preventive Services Task Force. Ann Intern Med 2013; 159: 824-834
    PubMedGoogle Scholar
  • 21 Arends JBH. Bischoff SC. Fietkau R. et al. S3-Leitline Klinische Ernährung in der Onkologie. Aktuel Ernahrungsmed 2015; 40: e1-e74
    Artikel in Thieme ConnectPubMedGoogle Scholar
  • 22 Giovannucci E. Chan AT. Role of vitamin and mineral supplementation and aspirin use in cancer survivors. J Clin Oncol 2010; 28: 4081-4085
    CrossrefPubMedGoogle Scholar
  • 23 Anderson AS. Craigie AM. Caswell S. et al. The impact of a bodyweight and physical activity intervention (BeWEL) initiated through a national colorectal cancer screening programme: randomised controlled trial. BMJ 2014; 348: g1823
    CrossrefPubMedGoogle Scholar
  • 24 Patel AV. Feigelson HS. Talbot JT. et al. The role of body weight in the relationship between physical activity and endometrial cancer: results from a large cohort of US women. Int J Cancer 2008; 123: 1877-1882
    CrossrefPubMedGoogle Scholar
  • 25 Gibson TM. Park Y. Robien K. et al. Body mass index and risk of second obesity-associated cancers after colorectal cancer: a pooled analysis of prospective cohort studies. J Clin Oncol 2014; 32: 4004-4011
    CrossrefPubMedGoogle Scholar
  • 26 Biesalski HK. Grune T. Tinz J. et al. Reexamination of a meta-analysis of the effect of antioxidant supplementation on mortality and health in randomized trials. Nutrients 2010; 2: 929-949
    CrossrefPubMedGoogle Scholar
  • 27 Bozzetti F. Screening the nutritional status in oncology: a preliminary report on 1,000 outpatients. Support Care Cancer 2009; 17: 279-284
    CrossrefPubMedGoogle Scholar
  • 28 Pirlich M. Schutz T. Norman K. et al. The German hospital malnutrition study. Clin Nutr 2006; 25: 628-572
    PubMedGoogle Scholar
  • 29 Ross PJ. Ashley S. Norton A. et al. Do patients with weight loss have a worse outcome when undergoing chemotherapy for lung cancers?. Br J Cancer 2004; 90: 1905-1911
    PubMedGoogle Scholar
  • 30 Marin Caro MM. Laviano A. Pichard C. Impact of nutrition on quality of life during cancer. Curr Opin Clin Nutr Metab Care 2007; 10: 480-487
    CrossrefPubMedGoogle Scholar
  • 31 Strohle A. Zanker K. Hahn A. Nutrition in oncology: the case of micronutrients (review). Oncol Rep 2010; 24: 815-828
    PubMedGoogle Scholar
  • 32 Biesalski HK. Mikronaehrstoffsupplemente bei onkologischen Patienten. Aktuel Ernahrungsmed 2011; 36: 282-285
    Artikel in Thieme ConnectPubMedGoogle Scholar
  • 33 Skrzydlewska E. Sulkowski S. Koda M. et al. Lipid peroxidation and antioxidant status in colorectal cancer. World J Gastroenterol 2005; 11: 403-406
    CrossrefPubMedGoogle Scholar
  • 34 Crew KD. Shane E. Cremers S. et al. High prevalence of vitamin D deficiency despite supplementation in premenopausal women with breast cancer undergoing adjuvant chemotherapy. J Clin Oncol 2009; 27: 2151-2156
    CrossrefPubMedGoogle Scholar
  • 35 Anthony HM. Schorah CJ. Severe hypovitaminosis C in lung-cancer patients: the utilization of vitamin C in surgical repair and lymphocyte-related host resistance. Br J Cancer 1982; 46: 354-367
    CrossrefPubMedGoogle Scholar
  • 36 Arnaud J. Bertrais S. Roussel AM. et al. Serum selenium determinants in French adults: the SU.VI. M.AX study. Br J Nutr 2006; 95: 313-320
    CrossrefPubMedGoogle Scholar
  • 37 Buntzel J. Riesenbeck D. Glatzel M. et al. Limited effects of selenium substitution in the prevention of radiation-associated toxicities. results of a randomized study in head and neck cancer patients. Anticancer Res 2010; 30: 1829-1832
    PubMedGoogle Scholar
  • 38 Muecke R. Schomburg L. Glatzel M. et al. Multicenter, phase 3 trial comparing selenium supplementation with observation in gynecologic radiation oncology. Int J Radiat Oncol Biol Phys 2010; 78: 828-835
    CrossrefPubMedGoogle Scholar
  • 39 Bischoff-Ferrari HA. Giovannucci E. Willett WC. et al. Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes. Am J Clin Nutr 2006; 84: 18-28
    CrossrefPubMedGoogle Scholar
  • 40 Manson JE. Brannon PM. Rosen CJ. et al. Vitamin D Deficiency — Is There Really a Pandemic?. N Engl J Med 2016; 375: 1817-1820
    CrossrefPubMedGoogle Scholar
  • 41 Carmel AS. Shieh A. Bang H. et al. The 25(OH)D level needed to maintain a favorable bisphosphonate response is >/=33 ng/ml. Osteoporos Int 2012; 23: 2479-2487
    CrossrefPubMedGoogle Scholar
  • 42 Bittenbring JT. Neumann F. Altmann B. et al. Vitamin D deficiency impairs rituximab-mediated cellular cytotoxicity and outcome of patients with diffuse large B-cell lymphoma treated with but not without rituximab. J Clin Oncol 2014; 32: 3242-3248
    CrossrefPubMedGoogle Scholar
  • 43 Kondrup J. Rasmussen HH. Hamberg O. et al. Nutritional risk screening (NRS 2002): a new method based on an analysis of controlled clinical trials. Clin Nutr 2003; 22: 321-336
    CrossrefPubMedGoogle Scholar
  • 44 van der Reest J. Gottlieb E. Anti-cancer effects of vitamin C revisited. Cell Res 2016; 26: 269-270
    CrossrefPubMedGoogle Scholar
  • 45 Ma Y. Chapman J. Levine M. et al. High-dose parenteral ascorbate enhanced chemosensitivity of ovarian cancer and reduced toxicity of chemotherapy. Sci Transl Med 2014; 6 DOI: 222ra18.
    CrossrefPubMedGoogle Scholar
  • 46 Vollbracht C. Schneider B. Leendert V. et al. Intravenous vitamin C administration improves quality of life in breast cancer patients during chemo-/radiotherapy and aftercare: results of a retrospective, multicentre, epidemiological cohort study in Germany. In Vivo 2011; 25: 983-990
    PubMedGoogle Scholar
  • 47 Drisko JA. Chapman J. Hunter VJ. The use of antioxidants with first-line chemotherapy in two cases of ovarian cancer. J Am Coll Nutr 2003; 22: 118-123
    CrossrefPubMedGoogle Scholar
  • 48 Vieira ML. Fonseca FL. Costa LG. et al. Supplementation with selenium can influence nausea, fatigue, physical, renal, and liver function of children and adolescents with cancer. J Med Food 2015; 18: 109-117
    CrossrefPubMedGoogle Scholar
  • 49 Dennert G. Horneber M. Selenium for alleviating the side effects of chemotherapy, radiotherapy and surgery in cancer patients. Cochrane Database Syst Rev 2006; DOI: CD005037.
    CrossrefPubMedGoogle Scholar
  • 50 Heaney ML. Gardner JR. Karasavvas N. et al. Vitamin C antagonizes the cytotoxic effects of antineoplastic drugs. Cancer Res 2008; 68: 8031-8038
    CrossrefPubMedGoogle Scholar
  • 51 Perrone G. Hideshima T. Ikeda H. et al. Ascorbic acid inhibits antitumor activity of bortezomib in vivo. Leukemia 2009; 23: 1679-1686
    CrossrefPubMedGoogle Scholar
  • 52 Löser C. Malnutrition in hospital: the clinical and economic implications. Dtsch Ärztebl Int 2010; 107: 911-917
    PubMedGoogle Scholar