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Zeitschrift für Komplementärmedizin 2018; 10(06): 46-52
DOI: 10.1055/a-0705-1458
Wissen
Säure-Basen-Dysbalance
© Karl F. Haug Verlag in MVS Medizinverlage Stuttgart GmbH & Co. KG

Mineralstoff- und Säure-Basen-Dysbalance als Risikofaktor für Wohlstandserkrankungen

Ludwig Manfred Jacob
Subject Editor:
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Publication History

Publication Date:
18 December 2018 (online)

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Summary

Chronische Störungen der Säure-Basen- und Mineralstoff-Homöostase verändern unzählige biochemische Reaktionen, die Funktion von Enzymen, Membranpotenziale und Gewebe. Meist treten sie schleichend auf, sodass sie lange unbemerkt bleiben. Zahlreiche wissenschaftliche Arbeiten zeigen, dass sie maßgeblich zur Entstehung von Wohlstandskrankheiten wie Hypertonie, Insulinresistenz, chronische Müdigkeit, aber auch Schmerzen, Gicht und Nierenerkrankungen beitragen können.

Zur Erhaltung der Homöostase eignet sich generell am besten eine pflanzenbetonte Ernährung mit viel Gemüse, Obst, Kräutern, Hülsenfrüchten und Nüssen, ggf. ist eine Substitution bestimmter Nährstoffe notwendig. Ähnlich essenziell sind regelmäßige Bewegung, tiefe Bauchatmung, Phasen der Regeneration und ausreichend guter Schlaf.

Keywords

Ernährung - Säure-Basen-Dysbalance - Mineralstoffhaushalt
 

  • Literatur

  • 1 Frassetto L, Morris Jr RC, Sellmeyer DE. et al Diet, evolution and aging – the pathophysiologic effects of the post-agricultural inversion of the potassium-to-sodium and base-to-chloride ratios in the human diet.. Eur J Nutr 2001; 40 (05) 200-213
    CrossrefPubMedGoogle Scholar
  • 2 Remer T, Manz F. Paleolithic diet, sweet potato eaters, and potential renal acid load.. Am J Clin Nutr 2003; 78 (04) 802-803 author reply 803–804
    CrossrefPubMedGoogle Scholar
  • 3 Sundelacruz S, Levin M, Kaplan DL. Role of membrane potential in the regulation of cell proliferation and differentiation.. Stem Cell Rev 2009; 5 (03) 231-246
    CrossrefPubMedGoogle Scholar
  • 4 Vormann J, Goedecke T. Acid-base homeostasis: latent acidosis as a cause of chronic diseases.. Schweiz Zschr GanzheitsMedizin 2006 18. (5)
    PubMedGoogle Scholar
  • 5 Luft FC, Zemel MB, Sowers JA. et al Sodium bicarbonate and sodium chloride: effects on blood pressure and electrolyte homeostasis in normal and hypertensive man.. J Hypertens 1990; 8 (07) 663-670
    CrossrefPubMedGoogle Scholar
  • 6 Krupp D, Shi L, Remer T. Longitudinal relationships between diet-dependent renal acid load and blood pressure development in healthy children.. Kidney Int 2014; 85 (01) 204-210
    CrossrefPubMedGoogle Scholar
  • 7 Jehle S, Zanetti A, Muser J. et al Partial neutralization of the acidogenic Western diet with potassium citrate increases bone mass in postmenopausal women with osteopenia.. J Am Soc Nephrol 2006; 17 (011) 3213-3222
    CrossrefPubMedGoogle Scholar
  • 8 de Vasconcellos K, Skinner DL. Hyperchloraemia is associated with acute kidney injury and mortality in the critically ill: A retrospective observational study in a multidisciplinary intensive care unit.. J Crit Care 2018; 45: 45-51
    CrossrefPubMedGoogle Scholar
  • 9 Barker ME. 0.9 % saline induced hyperchloremic acidosis.. J Trauma Nurs 2015; 22 (02) 111-116
    CrossrefPubMedGoogle Scholar
  • 10 Kendrick J, Kestenbaum B, Chonchol M. Phosphate and cardiovascular disease.. Adv Chronic Kidney Dis 2011; 18 (02) 113-119
    CrossrefPubMedGoogle Scholar
  • 11 Maurer M, Riesen W, Muser J. et al Neutralization of Western diet inhibits bone resorption independently of K intake and reduces cortisol secretion in humans.. Am J Physiol Renal Physiol 2003; 284 (01) F32-40
    CrossrefPubMedGoogle Scholar
  • 12 Sowers JR, Whaley-Connell A, Epstein M. Narrative review: the emerging clinical implications of the role of aldosterone in the metabolic syndrome and resistant hypertension.. Ann Intern Med 2009; 150 (011) 776-783
    Google Scholar
  • 13 Chhokar VS, Sun Y, Bhattacharya SK. et al Hyperparathyroidism and the calcium paradox of aldosteronism.. Circulation 2005; 111 (07) 871-878
    CrossrefPubMedGoogle Scholar
  • 14 Messaoudi S, Jaisser F. Aldosterone and the mineralocorticoid receptor.. Eur Heart J 2011; 13 (Suppl B) B4-B9
    CrossrefGoogle Scholar
  • 15 Whaley-Connell A, Johnson MS, Sowers JR. Aldosterone: role in the cardiometabolic syndrome and resistant hypertension.. Prog Cardiovasc Dis 2010; 52 (05) 401-409
    CrossrefPubMedGoogle Scholar
  • 16 Juraschek SP, Miller ER 3 rd, Weaver CM. et al Effects of sodium reduction and the DASH diet in relation to baseline blood pressure.. J Am Coll Cardiol 2017; 70 (023) 2841-2848
    CrossrefPubMedGoogle Scholar
  • 17 Sluka KA, Winter OC, Wemmie JA. Acid-sensing ion channels: A new target for pain and CNS diseases.. Curr Opin Drug Discov Devel 2009; 12 (05) 693-704
    PubMedGoogle Scholar
  • 18 Scialla JJ. et al. African American Study of Kidney Disease and Hypertension Study Group. Net endogenous acid production is associated with a faster decline in GFR in African Americans. Kidney Int 2012; 82 (01) 106-112
    CrossrefPubMedGoogle Scholar
  • 19 Mirmiran P, Yuzbashian E, Bahadoran Z. et al Dietary acid-base load and risk of chronic kidney disease in adults: Tehran Lipid and Glucose Study.. Iran J Kidney Dis 2016; 10 (03) 119-125
    PubMedGoogle Scholar
  • 20 Banerjee T, Crews DC, Wesson DE. et al Dietary acid load and chronic kidney disease among adults in the United States.. BMC Nephrol 2014; 15: 137
    CrossrefPubMedGoogle Scholar
  • 21 Lemann Jr. J, Bushinsky DA, Hamm LL. Bone buffering of acid and base in humans.. Am J Physiol Renal Physiol 2003; 285 (05) F811-832
    CrossrefPubMedGoogle Scholar
  • 22 Nagai T, Anzai T, Kaneko H. et al Impact of systemic acidosis on the development of malignant ventricular arrhythmias after reperfusion therapy for ST-elevation myocardial infarction.. Circ J 2010; 74 (09) 1808-1814
    CrossrefPubMedGoogle Scholar
  • 23 Rabenberg M, Mensink GBM. Obst- und Gemüsekonsum heute. Robert Koch-Institut Berlin, Hrsg.. GBE kompakt. 2011 2;(6) www.rki.de/gbe-kompakt(Stand:01.09.2011)
    Google Scholar
  • 24 Eaton SB, Eaton SB 3 rd, Konner MJ. Paleolithic nutrition revisited: a twelve-year retrospective on its nature and implications.. Eur J Clin Nutr 1997; 51 (04) 207-216
    CrossrefPubMedGoogle Scholar
  • 25 Willcox B, Willcox C, Todoriki H. et al Caloric restriction, the traditional Okinawan diet, and healthy aging: the diet of the world’s longest-lived people and its potential impact on morbidity and life span.. Ann NY Acad Sci 2007; 1114: 434-455
    CrossrefPubMedGoogle Scholar
  • 26 Mancilha-Carvalho JdeJ, Souza e Silva NA. The Yanomami Indians in the INTERSALT study.. Arq Bras Cardiol 2003; 80 (03) 289-300
    PubMedGoogle Scholar
  • 27 Intersalt Cooperative Research Group Intersalt: an international study of electrolyte excretion and blood pressure. Results for 24 hour urinary sodium and potassium excretion. BMJ 1988; 297 (6644) 319-328
    CrossrefPubMedGoogle Scholar
  • 28 Deutsche Gesellschaft für Ernährung. DGE aktualisiert die Referenzwerte für Natrium, Chlorid und Kalium. Presseinformation der Deutschen Gesellschaft für Ernährung e. V. vom 03.01.2017. https://www.dge.de/presse/pm/dge-aktualisiert-die-referenzwerte-fuer-natrium-chlorid-und-kalium/(abgerufenam18.04.2018)
  • 29 Institute of Medicine. Dietary Reference Intakes for Water, Potassium, Sodium, Chloride, and Sulfate. 2005; https://doi.org/10.17226/10925(abgerufenam17.04.2018)
    Crossref
  • 30 Gennari FJ, Cohen JJ. Role of the kidney in potassium homeostasis: lessons from acid-base disturbances.. Kidney Int 1975; 8 (01) 1-5
    CrossrefPubMedGoogle Scholar
  • 31 Ascherio A, Rimm EB, Hernán MA. et al Intake of potassium, magnesium, calcium, and fiber and risk of stroke among US men.. Circulation 1998; 98 (012) 1198-1204
    CrossrefPubMedGoogle Scholar
  • 32 Oberleithner H, Riethmuller C, Schillers H. et al Plasma sodium stiffens vascular endothelium and reduces nitric oxide release.. Proc Natl Acad Sci U S A 2007; 104 (041) 16281-16286
    CrossrefPubMedGoogle Scholar
  • 33 Oberleithner H, Callies C, Kusche-Vihrog K. et al Potassium softens vascular endothelium and increases nitric oxide release.. Proc Natl Acad Sci U S A 2009; 106 (08) 2829-2834
    CrossrefPubMedGoogle Scholar
  • 34 Jayedi A, Ghomashi F, Zargar MS. et al Dietary sodium, sodium-to-potassium ratio, and risk of stroke: A systematic review and nonlinear dose-response meta-analysis.. Clin Nutr 2018 doi: 10.1016/j.clnu.2018.05.017
    PubMedGoogle Scholar
  • 35 Jacob Dr LM. Jacobs Weg des genussvollen Verzichts: Die effektivsten Maßnahmen zur Prävention und Therapie von Zivilisationskrankheiten. 3. Aufl.. Heidesheim am Rhein: Nutricamedia; 2013
    Google Scholar
  • 36 Schurgers LJ, Barreto DV, Barreto FC. et al The circulating inactive form of matrix gla protein is a surrogate marker for vascular calcification in chronic kidney disease: a preliminary report.. Clin J Am Soc Nephrol 2010; 5 (04) 568-575
    CrossrefPubMedGoogle Scholar