Endoscopy
DOI: 10.1055/a-0725-7995
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© Georg Thieme Verlag KG Stuttgart · New York

Assessment of Barrett’s esophagus and dysplasia with ultrahigh-speed volumetric en face and cross-sectional optical coherence tomography

Osman O. Ahsen
1  Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States
,
Kaicheng Liang
1  Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States
,
Hsiang-Chieh Lee
1  Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States
,
Michael G. Giacomelli
1  Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States
,
Zhao Wang
1  Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States
,
Benjamin Potsaid
1  Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States
2  Thorlabs, Inc., Newton, New Jersey, United States
,
Marisa Figueiredo
3  VA Boston Healthcare System, Boston, Massachusetts, United States
,
Qin Huang
3  VA Boston Healthcare System, Boston, Massachusetts, United States
4  Harvard Medical School, Boston, Massachusetts, United States
,
Vijaysekhar Jayaraman
5  Praevium Research, Inc., Santa Barbara, California, United States
,
James G. Fujimoto
1  Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States
,
Hiroshi Mashimo
3  VA Boston Healthcare System, Boston, Massachusetts, United States
4  Harvard Medical School, Boston, Massachusetts, United States
› Author Affiliations
Further Information

Publication History

submitted 09 November 2017

accepted after revision 31 July 2018

Publication Date:
27 September 2018 (eFirst)

Background This study aimed to evaluate the use of ultrahigh-speed volumetric en face and cross-sectional optical coherence tomography (OCT) with micromotor catheters for the in vivo assessment of Barrett’s esophagus and dysplasia.

Methods 74 OCT datasets with correlated biopsy/endoscopic mucosal resection histology (49 nondysplastic Barrett’s esophagus [NDBE], 25 neoplasia) were obtained from 14 patients with Barrett’s esophagus and a history of dysplasia and 30 with NDBE. The associations between irregular mucosal patterns on en face OCT, absence of mucosal layering, surface signal > subsurface, and > 5 atypical glands on cross-sectional OCT vs. histology and treatment history were assessed by three blinded readers.

Results Atypical glands under irregular mucosal patterns occurred in 75 % of neoplasia (96 % of treatment-naïve neoplasia) vs. 30 % of NDBE datasets (43 % of short- and 18 % of long-segment NDBE). Mucosal layering was absent in 35 % of neoplasia and 50 % of NDBE datasets, and surface signal > subsurface occurred in 29 % of neoplasia and 30 % of NDBE datasets.

Conclusions Atypical glands under irregular mucosal patterns are strongly associated with neoplasia, suggesting potential markers for dysplasia and a role in pathogenesis.

Fig. e1, e2, e4, e6, Table e1–e6, e8–e12, Appendix e1–e10