CC BY-NC-ND 4.0 · Endosc Int Open 2019; 07(01): E43-E48
DOI: 10.1055/a-0746-3329
Case report
Owner and Copyright © Georg Thieme Verlag KG 2019

Natural history of early gastric cancer: series of 21 cases

Hiroyoshi Iwagami
1   Division of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan
,
Ryu Ishihara
1   Division of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan
,
Kentaro Nakagawa
1   Division of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan
,
Masayasu Ohmori
1   Division of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan
,
Kenshi Matsuno
1   Division of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan
,
Shuntaro Inoue
1   Division of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan
,
Masamichi Arao
1   Division of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan
,
Taro Iwatsubo
1   Division of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan
,
Hiroko Nakahira
1   Division of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan
,
Noriko Matsuura
1   Division of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan
,
Satoki Shichijo
1   Division of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan
,
Akira Maekawa
1   Division of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan
,
Kanesaka Takashi
1   Division of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan
,
Sachiko Yamamoto
1   Division of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan
,
Yoji Takeuchi
1   Division of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan
,
Koji Higashino
1   Division of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan
,
Noriya Uedo
1   Division of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan
,
Isao Miyashiro
2   Division of Cancer Control Center, Osaka International Cancer Institute, Osaka, Japan
› Author Affiliations
Further Information

Publication History

submitted 26 February 2018

accepted after revision 22 August 2018

Publication Date:
03 January 2019 (online)

Abstract

Background and study aims While knowledge of the natural history of early gastric cancer (EGC) may be useful in relevant clinical situations, few relevant reports are available. Therefore, we investigated the progression of EGC. We gathered data regarding 114 cases of EGC from 2005 to 2015 from a hospital cancer registry and analyzed 21 lesions that fulfilled five inclusion criteria. Deep progression was defined as submucosal invasion by a mucosal tumor and proper muscle invasion by a submucosal tumor. Lateral progression was defined as ≥ 20 % increase in size. During median follow-up of 23 months, one of 18 mucosal tumors showed deep progression and six showed lateral progression. Of three submucosal tumors, two showed deep progression and three showed lateral progression. Our study suggests that a certain proportion of mucosal cancers can lie dormant for several years. Further large-scale studies in a multicenter setting should overcome the limitations of this study.