Cervical esophageal adenocarcinoma arising from heterotopic gastric mucosa, treated with endoscopic submucosal dissection
23 November 2018 (eFirst)
Esophageal adenocarcinoma arising from heterotopic gastric mucosa (HGM) is extremely rare  . We describe a case of esophageal adenocarcinoma arising from HGM in the cervical esophagus that was treated with endoscopic submucosal dissection (ESD).
A 58-year-old man found to have an esophageal tumor on endoscopy was referred to our hospital for further examination and treatment. Conventional endoscopy revealed circumferential HGM of the cervical esophagus and a 20-mm protruding lesion in the posterior wall. Poorly defined reddish mucosa surrounded the protruding lesion ([Fig. 1 a]). Spraying with indigo carmine visualized the flat lesion in the reddish mucosa, but the demarcation line was unclear ([Fig. 1 b]). Narrow-band imaging (NBI) revealed a clearly demarcated brownish area consistent with the reddish area at 18 – 21 cm from the upper incisors, with villous and glandular structures of various sizes and dense distribution of abnormal capillaries ([Fig. 1 c, d]). Biopsy showed adenocarcinoma, with no evidence of deep submucosal invasion. Therefore, ESD was performed using a dual knife (KD-655L; Olympus, Tokyo, Japan) and an ITknife nano (KD-612; Olympus, Tokyo, Japan) ([Video 1]). The resected specimen measured 51 × 35 mm and contained a macroscopically measured 32 × 27-mm tumor surrounded by HGM. Histologically, the tumor cells showed well-differentiated adenocarcinoma in the muscularis mucosa ([Fig. 2]). Immunohistochemically, the tumor cells were positive for mucin (MUC) 2, MUC5AC, and MUC6.
Video 1 Endoscopic submucosal dissection of cervical esophageal adenocarcinoma arising from heterotopic gastric mucosa.
The estimated incidence of HGM of the esophagus is 0.75 % – 11 % based on endoscopic studies  . Primary adenocarcinoma arising from HMG is rare and several cases of mucosal cancer have been reported   . The macroscopic appearance was protruding or polypoid in most cases ; therefore, adenocarcinoma should be suspected when a protrusion is identified in HGM in the esophagus.
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- 1 Noguchi T, Takeno S, Takahashi Y. et al. Primary adenocarcinoma of the cervical esophagus arising from heterotopic gastric mucosa. J Gastroenterol 2001; 36: 704-709
- 2 Yasar B, Tarcin O, Benek D. et al. Intramucosal adenocarcinoma arising from ectopic gastric mucosa in the upper esophagus treated successfully with endoscopic mucosal resection. J Gastrointest Cancer 2014; 45 (Suppl. 01) 201-204
- 3 Weickert U, Wolf A, Schroder C. et al. Frequency, histopathological findings, and clinical significance of cervical heterotopic gastric mucosa (gastric inlet patch): a prospective study in 300 patients. Dis Esophagus 2011; 24: 63-68
- 4 Yu L, Yang Y, Cui L. et al. Heterotopic gastric mucosa of the gastrointestinal tract: prevalence, histological features, and clinical characteristics. Scand J Gastroenterol 2014; 49: 138-144
- 5 Kadota T, Fujii S, Oono Y. et al. Adenocarcinoma arising from heterotopic gastric mucosa in the cervical esophagus and upper thoracic esophagus: two case reports and literature review. Expert Rev Gastroenterol Hepatol 2016; 10: 405-414