Geburtshilfe Frauenheilkd 2019; 79(10): 1043-1060
DOI: 10.1055/a-0882-4116
GebFra Science
Georg Thieme Verlag KG Stuttgart · New York

Sarcoma of the Uterus. Guideline of the DGGG and OEGGG (S2k Level, AWMF Register Number 015/074, February 2019)

Article in several languages: English | deutsch
Dominik Denschlag
1   Frauenklinik, Hochtaunuskliniken Bad Homburg, Bad Homburg, Germany
Sven Ackermann
2   Frauenklinik, Klinikum Darmstadt, Darmstadt, Germany
Marco Johannes Battista
3   Universitätsmedizin Mainz, Klinik und Poliklinik für Geburtshilfe und Frauengesundheit, Mainz, Germany
Wolfgang Cremer
4   Berufsverband der Frauenärzte, Hamburg, Germany
Gerlinde Egerer
5   Universitätsklinik Heidelberg, Heidelberg, Germany
Markus Follmann
6   Deutsche Krebsgesellschaft, Berlin, Germany
Heidemarie Haas
7   Frauenselbsthilfe nach Krebs e. V., Erlangen, Germany
Philipp Harter
8   Klinik für Gynäkologie und Gynäkologische Onkologie, Kliniken Essen Mitte, Essen, Germany
Simone Hettmer
9   Universitätsklinik Freiburg, Freiburg, Germany
Lars-Christian Horn
10   Abteilung für Mamma-, Urogenital, und Perinatalpathologie, Institut für Pathologie, Universitätsklinikum Leipzig, Leipzig, Germany
Ingolf Juhasz-Boess
11   Klinik für Gynäkologie, Geburtshilfe und Reproduktionsmedizin, Universitätsklinikum des Saarlandes, Homburg/Saar, Germany
Karin Kast
12   Universitätsklinik Dresden, Dresden, Germany
Günter Köhler
13   Deutsches klinisches Kompetenzzentrum für genitale Sarkome und Mischtumoren, Universitätsmedizin Greifswald, Greifswald, Germany
Thomas Kröncke
14   Klinik für Radiologie, Klinikum Augsburg, Augsburg, Germany
Katja Lindel
15   Klinik für Radioonkologie, Klinikum Karlsruhe, Karlsruhe, Germany
Peter Mallmann
16   Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe, Universitätsklinikum Köln, Köln, Germany
Regine Meyer-Steinacker
17   Universitätsklinik Ulm, Ulm, Germany
Alexander Mustea
18   Universitäts-Frauenklinik Greifswald, Greifswald, Germany
Edgar Petru
19   Universitäts-Frauenklinik Graz, Graz, Austria
Peter Reichardt
20   Klinik für interdisziplinäre Onkologie, Helios Kliniken Berlin-Buch, Berlin, Germany
Dietmar Schmidt
21   Institut für Pathologie Viersen, Viersen, Germany
Hans-Georg Strauss
22   Klinik und Poliklinik für Gynäkologie, Universitätsklinikum Halle, Halle/Saale, Germany
Clemens Tempfer
23   Universitäts-Frauenklinik Bochum, Bochum, Germany
Falk Thiel
24   Frauenklinik, Alb Fils Kliniken, Göppingen, Germany
Uwe Ulrich
25   Klinik für Gynäkologie und Geburtshilfe, Martin-Luther-Krankenhaus Berlin, Paul Gerhardt Diakonie, Berlin, Germany
Thomas Vogl
26   Institut für diagnostische und interventionelle Radiologie, Universitätsklinikum Frankfurt, Frankfurt/Main, Germany
Dirk Vordermark
27   Universitätsklinik und Poliklinik für Strahlentherapie, Universitätsklinikum Halle, Halle/Saale, Germany
Paul Gass
28   Frauenklinik, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg; Comprehensive Cancer Center (CCC) Erlangen-EMN, Erlangen, Germany
Matthias W. Beckmann
28   Frauenklinik, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg; Comprehensive Cancer Center (CCC) Erlangen-EMN, Erlangen, Germany
› Author Affiliations
Further Information

Publication History

received 21 March 2019

accepted 22 March 2019

Publication Date:
22 October 2019 (online)


Aims This is an official guideline published and coordinated by the German Society of Gynecology and Obstetrics (DGGG) and the Austrian Society of Gynecology and Obstetrics (OEGGG). Because of their rarity and heterogeneous histopathology, uterine sarcomas are challenging in terms of how they should be managed clinically, and treatment requires a multidisciplinary approach. To our knowledge, there are currently no binding evidence-based recommendations for the appropriate management of this heterogeneous group of tumors.

Methods This S2k guideline was first published in 2015. The update published here is the result of the consensus of a representative interdisciplinary group of experts who carried out a systematic search of the literature on uterine sarcomas in the context of the guidelines program of the DGGG, OEGGG and SGGG. Members of the participating professional societies achieved a formal consensus after a moderated structured consensus process.

Recommendations The consensus-based recommendations and statements include the epidemiology, classification, staging, symptoms, general diagnostic work-up and general pathology of uterine sarcomas as well as the genetic predisposition to develop uterine sarcomas. Also included are statements on the management of leiomyosarcomas, (low and high-grade) endometrial stromal sarcomas and undifferentiated uterine sarcomas and adenosarcomas. Finally, the guideline considers the follow-up and morcellation of uterine sarcomas and the information provided to patients.

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