Drug Res (Stuttg) 2020; 70(04): 174-177
DOI: 10.1055/a-1112-7006
Original Article
© Georg Thieme Verlag KG Stuttgart · New York

Antibiotic Susceptibility of Bacterial Agents Causing Meningitis in Children Older than 1 Month

Reihaneh Mohsenipour
1  Department of Pediatric Endocrinology, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran
,
Behdad Gharib
2  Department of Pediatrics, School of Medicine, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran
,
Hamid Eshaghi
2  Department of Pediatrics, School of Medicine, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran
,
3  Pediatric Gastroenterology and Hepatology Research Center, Tehran University of Medical Sciences, Tehran, Iran
› Author Affiliations
Further Information

Publication History

received 26 October 2019

accepted 31 January 2020

Publication Date:
28 February 2020 (online)

Abstract

The frequency and antibiotic susceptibility of bacterial meningitis in children older than one month at Children's Medical Center during 2012–2017 were evaluated in this study. The CSF samples were cultured, and antibiotic sensitivity tests were performed. The samples were cultured on chocolate agar, blood agar (for gram positive) and Mkanky (for gram negative). The antimicrobial susceptibility of the isolates was determined using the disc diffusion method. In total, 72 samples were positive for bacterial infection where Staphylococcus epidermidis (20.8%) was seen most and Enterobacter (1.4%) and Pseudomonas aeruginosa (1.4%) was seen least. Most of these patients were under 1 year of the age and overall frequency of positive cultures of CSF in men (58.3%) was greater than women (41.7%). Bacterial meningitis has relatively diverse etiological factors that include; time of infection, geographical location and age. Most commonly seen bacteria were Staphylococcus aureus with S.epidermidis whereas, Escherichia coli and Pseudomonas aeruginosa was seen least. This result can be substantial in hospitalized patients, because these bacteria are also the result of nosocomial infections.