Endoscopy 2021; 53(02): E71-E72
DOI: 10.1055/a-1193-4456
E-Videos

The “double string” sign: a warning image after cold endoscopic mucosal resection

Óscar Nogales Rincón
Department of Gastroenterology, Endoscopy Unit, Hospital General Universitario Gregorio Marañón, Madrid, Spain
,
Julia García García
Department of Gastroenterology, Endoscopy Unit, Hospital General Universitario Gregorio Marañón, Madrid, Spain
,
Olga Ortega Lobete
Department of Gastroenterology, Endoscopy Unit, Hospital General Universitario Gregorio Marañón, Madrid, Spain
,
Carlos Carbonell Blanco
Department of Gastroenterology, Endoscopy Unit, Hospital General Universitario Gregorio Marañón, Madrid, Spain
,
Laura Rayón Moreno
Department of Gastroenterology, Endoscopy Unit, Hospital General Universitario Gregorio Marañón, Madrid, Spain
,
Javier Aranda Hernández
Department of Gastroenterology, Endoscopy Unit, Hospital General Universitario Gregorio Marañón, Madrid, Spain
,
Beatriz Merino Rodríguez
Department of Gastroenterology, Endoscopy Unit, Hospital General Universitario Gregorio Marañón, Madrid, Spain
› Author Affiliations

A 52-year-old man underwent screening colonoscopy. A sessile serrated lesion (Paris 0-Is, NICE-1; 17 mm diameter) was observed in the right colon. After submucosal injection with gelofusine plus indigo carmine, en bloc cold endoscopic mucosal resection (cold-EMR) was attempted using a 25-mm braided snare (SnareMaster SD-210U-25; Olympus, Tokyo, Japan) ([Fig. 1]). After snare closure, moderate traction of the snare sheath was applied to remove the lesion; however, the lesion remained trapped due to a large amount of tissue caught. The snare was repositioned slightly, and resection was successful. On inspection of the mucosal defect, the submucosal layer was observed with apparent “bubble sign” after waterjet irrigation ([Fig. 2 a], [Video 1]), followed by a “double string” sign, suggesting exposure of damaged muscle fibers ([Fig. 2 b]). After insufflation and water irrigation, these muscle fibers separated showing deep muscular injury with visible serosa ([Fig. 2 c]). The defect was immediately closed with endoscopic clips ([Fig. 2 d]). The patient was monitored for 4 hours and discharged with prophylactic antibiotics and no symptoms. No complications occurred. Histology confirmed a 21 × 12 × 2 mm specimen and suspicion of serrated lesion without dysplasia.

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Fig. 1 Sessile serrated lesion Paris 0-Is, NICE-1, in the right colon.
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Fig. 2 The mucosal defect after cold endoscopic mucosal resection. a Submucosal layer with apparent “bubble sign” after waterjet irrigation. b Injured muscle layer, “double string” image. c Perforation site. d Complete endoscopic closure with clips.

Video 1 The “double string” sign and perforation after cold endoscopic mucosal resection.


Quality:

Colonic perforation after cold-EMR is infrequent [1] [2] [3] [4]. The description of a new sign in the mucosal defect (“double string sign”) after cold-EMR should alert endoscopists to prevent delayed perforation. The sign refers to bundles of muscle fibers with loose disposition within the mucosal defect that indicates deep injury to the muscular layer. This is caused by a combination of snare closure and excessive traction applied to remove the tissue. The use of specifically designed snares for cold snare polypectomy with greater excision ability (without the need for traction of the snare sheath) [1] and tissue resections < 15 mm could decrease the risk of injury to the muscular layer during cold-EMR.

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Publication History

Publication Date:
19 June 2020 (online)

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