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Klin Padiatr 2020; 232(05): 275-278
DOI: 10.1055/a-1210-2639
Short Communication

COVID-19 in a Child with Pre-Existing Immunodeficiency, Cardiomyopathy, and Chronic Pulmonary Disease

COVID-19 bei einem Kind mit vorbestehendem Immundefekt, Kardiomyopathie und chronischer Lungenerkrankung

Authors

  • Lars Dinkelbach

    1   Department of Pediatric Oncology, Hematology and Clinical Immunology, Centre for Child and Adolescent Health, University Hospital, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Düsseldorf
    2   Centre for Child and Adolescent Health, HELIOS Klinikum, Krefeld, Krefeld

  • Julia Franzel

    3   Department of General Pediatrics, Neonatology and Pediatric Cardiology, University Hospital, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Düsseldorf

  • Martin Andree Berghäuser

    4   Department of Pediatrics, Florence-Nightingale-Hospital, Düsseldorf, Düsseldorf

  • Thomas Hoehn

    3   Department of General Pediatrics, Neonatology and Pediatric Cardiology, University Hospital, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Düsseldorf

  • Sujal Ghosh

    1   Department of Pediatric Oncology, Hematology and Clinical Immunology, Centre for Child and Adolescent Health, University Hospital, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Düsseldorf

  • Unaa Lee

    3   Department of General Pediatrics, Neonatology and Pediatric Cardiology, University Hospital, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Düsseldorf

  • Dominik Wulf

    3   Department of General Pediatrics, Neonatology and Pediatric Cardiology, University Hospital, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Düsseldorf

  • Jörg Schaper

    5   Department of Diagnostic and Interventional Radiology, University Hospital, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Düsseldorf

  • Björn Jensen

    6   Department of Gastroenterology, Hepatology and Infectious Diseases, University Hospital, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Düsseldorf

  • Tim Niehues

    2   Centre for Child and Adolescent Health, HELIOS Klinikum, Krefeld, Krefeld

  • Felix Distelmaier

    3   Department of General Pediatrics, Neonatology and Pediatric Cardiology, University Hospital, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Düsseldorf

  • Jennifer Neubert

    1   Department of Pediatric Oncology, Hematology and Clinical Immunology, Centre for Child and Adolescent Health, University Hospital, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Düsseldorf
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Background

Comorbidities like cardiovascular and respiratory diseases, diabetes or active cancer were identified as major risk factors for SARS-CoV-2 related morbidity and mortality in adults (Onder G et al., JAMA 2020). In children, no risk factors for COVID-19 have been defined so far.

We describe the clinical course of COVID-19 in a 7-year-old boy with autosomal recessively inherited folliculin interacting protein 1 (FNIP1) deficiency whose phenotype is characterized by conditions associated with a more severe outcome of COVID-19.



Publikationsverlauf

Artikel online veröffentlicht:
06. August 2020

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