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Drug Res (Stuttg) 2020; 70(10): 463-471
DOI: 10.1055/a-1213-2206
Original Article

Trends of Antimicrobial Resistance of Sepsis Pathogens at a University Hospital in New Delhi, India

Md Shamshir Alam
1   Department of Pharmacology, Faculty of Pharmacy, Jamia Hamdard, New Delhi, India
2   Department of Pharmacy Practice, MM College of Pharmacy, Maharishi Markandeshwar (Deemed to be University), Mullana, India
,
Prem Kapur
3   Department of Medicine, Hamdard Institute of Medical Sciences & Research and Hakeem Abdul Hameed Centenary Hospital, Hamdard University, New Delhi, India
,
ParuKutty Pillai
4   Department of Microbiology, Majeedia Hospital, Jamia Hamdard, New Delhi, India
5   Department of Microbiology, LHMC, New Delhi, India
,
Krishna Kolappa Pillai
1   Department of Pharmacology, Faculty of Pharmacy, Jamia Hamdard, New Delhi, India
› Author Affiliations Sources of Funding The financial support by the University Grants Commission, New Delhi (Grant No. F. 4–1/2006 (BSR)/11–26/2008(BSR) is gratefully acknowledged by the authors.
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Abstract

Knowledge of the aetiological agents and its susceptibility to antimicrobial agents enables the clinician to initiate appropriate empirical antimicrobial therapy and guides diagnostic procedures. The aims of the study were to identify prevalence of bacterial pathogens causing sepsis and observe their antimicrobial resistance trends in hospitalized patients. A prospective cohort study was conducted on patients of sepsis admitted at a university hospital over a period of six months. Pathogens were identified by morphological, biochemical and serological tests as per the American Society for Microbiology. Antibacterial sensitivity of bacterial strains isolated from clinically diagnosed sepsis was carried out by Kirby-Bauer disk diffusion method and interpreted according Clinical and Laboratory Standards Institute guidelines. The data were analyzed by using Statistical Package for Social Sciences, version 16.0 (SPSS 16.0, Chicago, IL, USA). Coagulase negative Staphylococcus (63.5%) and Staphylococcus aureus (23.1%) were the most frequently isolated Gram positive bacteria. Acinetobacter species (31%) and Salmonella typhi (24.1%) were the most frequently isolated Gram negative bacteria. Coagulase negative Staphylococcus showed significant resistance to ciprofloxacin and tetracycline. Acinetobacter species showed significant resistance to ampicillin, amoxicillin and amoxiclav. Salmonella typhi showed significant resistance to ampicillin, amoxicillin, cefotaxime, netilmicin and, tetracycline. Escherichia coli showed significant resistance to ampicillin and netilmicin. All the stains of Staphylococcus aureus were resistant to amoxicillin. Coagulase negative Staphylococcus and Acinetobacter species were predominant Gram positive and Gram negative bacteria, respectively, causing sepsis. Increasing rates of bacterial resistance to commonly use antimicrobial agents were observed.

Key words

infectious diseases - antibacterial drugs - drug research


Publication History

Received: 06 November 2019

Accepted: 28 June 2020

Article published online:
13 August 2020

© 2020. Thieme. All rights reserved.

© Georg Thieme Verlag KG
Stuttgart · New York

 

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