Endoscopy 2021; 53(06): 647-651
DOI: 10.1055/a-1248-2138
Innovations and brief communications

A novel technique for mapping biopsy of bile duct cancer

Hirokazu Okada
1  Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan
,
Norimitsu Uza
1  Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan
,
Tomoaki Matsumori
1  Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan
,
Shimpei Matsumoto
1  Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan
,
Yuya Muramoto
1  Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan
,
Sakiko Ota
1  Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan
,
Takeharu Nakamura
1  Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan
,
Hiroyuki Yoshida
1  Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan
,
Tomonori Hirano
1  Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan
,
Takeshi Kuwada
1  Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan
,
Saiko Marui
1  Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan
,
Yuko Sogabe
1  Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan
,
Toshihiro Morita
1  Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan
,
Nobuyuki Kakiuchi
1  Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan
,
Atsushi Mima
1  Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan
,
Tatsuki Ueda
1  Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan
,
Yoshihiro Nishikawa
1  Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan
,
Motoyuki Tsuda
1  Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan
,
Takahisa Maruno
1  Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan
,
Masahiro Shiokawa
1  Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan
,
Ken Takahashi
1  Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan
,
Kojiro Taura
2  Department of Hepato-pancreato-biliary Surgery and Transplantation, Kyoto University Graduate School of Medicine, Kyoto, Japan
,
Sachiko Minamiguchi
3  Department of Diagnostic Pathology, Kyoto University Graduate School of Medicine, Kyoto, Japan
,
Yuzo Kodama
4  Department of Gastroenterology, Kobe University Graduate School of Medicine, Kobe, Japan
,
Hiroshi Seno
1  Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan
› Author Affiliations

Abstract

Background Accurate preoperative assessment of the longitudinal extension of perihilar cholangiocarcinoma (PHCC) is essential for treatment planning. Mapping biopsies for PHCC remain challenging owing to technical difficulties and insufficient sample amounts. The aim of this study was to investigate the usefulness of a novel technique for mapping biopsies of PHCC.

Methods Our novel method focused on a biliary stent delivery system for mapping biopsies. Fifty patients with PHCC undergoing endoscopic transpapillary mapping biopsy using the novel method were reviewed from August 2015 to June 2019.

Results The median number of biopsy samples was six (range 1 – 17), and the rate of adequate sampling was 91.4 % (266 /291). Biopsy from the intrahepatic bile duct was possible in 82.0 % of patients (41 /50), and negative margins were confirmed in the resected specimens from 34 /39 patients who underwent surgery (87.2 %). None of the patients had post-endoscopic retrograde cholangiopancreatography pancreatitis.

Conclusions With our novel method, accurate assessment of the longitudinal extension of PHCC might be expected with minimal trauma to the duodenal papilla.

Supplementary material



Publication History

Received: 25 March 2020

Accepted: 29 July 2020

Publication Date:
22 September 2020 (online)

© 2020. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany